Simponi... it's now working, how is everyone doing on it?

That is awesome!!
B

Day 8, still holding and feeling good!...although I do have to learn to not eat a Jimmy John's 'unwich' (all lettuce, no bread) for lunch followed by a dinner of cabbage rolls....a little too much roughage in one day while healing......

I am so happy to hear about your good results. I haven't heard of simponi before and now I know that it's another option available if I need it. Thank you for your day to day descriptions, I think they will help a lot of us. There is a lot of bad news on this forum, seeing positive results makes me feel really happy.

Day 9, had a rough day yesterday because I ate waaay too much of crap I shouldn't have. But, all in all, the only thing that happened was a bit of a tummy ache, nothign serious, frequent trips to the bathroom and some loose diarrhea..nothing major, and it cleared up after each trip.

This morning I woke up feeling pretty good....Simponi is holding, and I do my second injection in 6 more days.

How is everyone else doing on this?

Well, what is it, day 9? A little set back the last day or two, back to some diarrhea, but no stomach ache. I'm going 4-5 times a day with pretty watery stools, but I do have to say that I have no pain. I didn't expect this to cure me right away, but I am going pain free for the day, which is most important.

Also, no urgency which is the BIG thing. I'll be watching movie and actually wait an hour to go......lol. My next shot is in 5 days, so maybe that will jar it into submission totally. I'm not worried, this has really cleared it up a lot. The way this seems to be working is that it gives me longer and longer blocks of time where I see symptomatic remissions, then I go back to the old ways, but less severe...then into symptomatic remissions that last longer.

Still...overall I am so much better than 9 days ago when I started this!!

Well, Simponi shows it's working again....BLAM!

At noon yesterday, it was like a wall came down and I was in symptomatic remission after a sketchy 3 days of on and off mild (no urgency, just diarrhea and mild tummy ache) discomfort....what a weird drug, but hey...I'll take it as it starts working for me.

It seemed to start working after 5 days, showing brief periods of working for hours at a time, then full symptomatic remission at day 7, slipping slightly back to some mild flare symptoms at day 9, 10, and half of day 11, then day 11 it just stopped the symptoms in it's tracks again.... I didn't even realize it till that night when I went to bed, I was like, hey!...I felt fine since about 2pm today!

Woke up this morning (at freaking 9:00) feeling wonderful again, no pooping or anything....next shot is Wednesday, looking forward to it!

It appears (to me anyway), that Simponi works in clumps of hours/days at a time rather than slowly calming down the disease...anyone else have this effect?

Monday, Day 12 after initial 200mg loading dose...back into symptomatic remission for the last 2 days, it's teasing me again!

I think the way this is working is that it works in chunks of time. I noticed that it started by working for an hour, then a few hours, then for a day, then a few days. Each time I slipped back into some "flare", it was less and less than what it was the time before. Today I woke up, no discomfort, pooped a bit (fairly small but normal), and went about my life. I feel good this morning, maybe that slight discomfort... or is it anxiety in our heads that we all have just thinking about it (when will they come up with something to fix that, aside from psych meds?!?).

I'd give this drug so far an 9/10, my next loading dose is Wednesday...looking to get over the hump with that one, and push myself into total symptomatic remission!

I am a newbee here. Glad to hear of your success. I had my 1st loading 200 mg of Simponi on Feb 7th the second on Feb 21st and am waiting for my 3rd on March 21. I still have a lot of symptoms. The only other med I take is Mezevant. I really want to steer clear of the roids.

Good deal man. Hope it continues working. That's my next drug after I start this Humira that's still sitting in my fridge.

i'm supposed to take my 4th shot tomorrow but have to wait for these stool samples i got today. they will probably be back in a few days.

after all night of pooping, i had a normal poop at noon and have been fine all day. definitely exhausted, but no belly pains, gas, cramps whatsoever. i think it was just a bad bout of food poisoning.

i will take my next shot when my stool samples come back clear, i hope.

Hope it keeps working for you. Fingers crossed :)
I have UC -have had for 25+ years. This (which is the worst flare I have ever had) flare started shortly after Sept 2010 when I quit smoking?? How wierd is that - and have tried EVERYTHING!!! Very frustrating.
asacol, pentasa, enamas, mezevant, prednisone, you-name it, and now simponi

Thanks for posting Scott. My daughter is scheduled to begin on Monday. Were there side effects that would keep her from going to work the next day? I wish she could start on a Friday, she doesn't like missing work.
Thanks

I did not find the side effects too bad. It is good practice to do take it at night before bed; then just sleep thru most of the side effects. At least I find that works for me.