New treatments for Colitis

imagardener2 said...
I went googling because I knew nothing about this therapy. Sounds very promising and was in Phase III trials in the US as of 2008 so what's happened since then??

Here's a link to the paper dated 2008
www.ncbi.nlm.nih.gov/pmc/articles/PMC2738785/

Here are a few sentences that stood out to me (underlining is mine):

Transplant conditioning calls for an aggressive immunosuppression regimen that may play a role in inducing remission, but patients with severely impaired mucosal barrier function undergoing such a regimen may worsen their plight and face even more severe consequences. .........

Adipose tissue-derived MSCs[101] have been shown to possess promising potential for ulceration healing in perianal manifestations. .......

ProchymalTM, developed by Osiris Therapeutics Inc.[75], is a preparation for intravenous infusion of bone marrow-derived MSCs obtained from healthy adult donors. ..... One-third of the patients reported Inflammatory Bowel Disease Questionnaire (IBDQ) scores of at least 170, indicating they had achieved clinical remission of their disease.

Sounds very promising and was in Phase III trials in the US as of 2008 so what's happened since then??

Here's one explanation:
www.lef.org/magazine/mag2011/jan2011_Potential-Arthritis-Treatment-Advance-Blocked-by-FDA_01.htm?source=search&key=stem%20cells
A new therapy might reverse this trend. The technology is called autologous stem cell transplantation. It involves using undifferentiated cells that can develop into almost any tissue—new cartilage, tendons, ligaments, even bone—to replace damaged, arthritic joints. These cells are taken not from human embryos but from your own body!

At the forefront of this research is Colorado-based regenerative medical expert Dr. Christopher Centeno. His clinical work has already yielded intriguing preliminary results—up to 75% pain reduction without surgery or side effects in scores of patients.

In this article, the facets of Dr. Centeno’s new therapy are detailed. You will then learn of the FDA’s inhumane attempt to block Dr. Centeno from using this experimental therapy. In this instance, the FDA is erecting a regulatory barrier to deny patients access to their own stem cells—in all likelihood to protect drug company profits.

Post Edited (BabeintheWoods) : 6/14/2012 6:25:07 AM (GMT-6)

So it's the same stem cell treatment I heard about on the news, but on the news they only mentioned using it for arthritis/osteo and I thought to myself, those are awful diseases to live with but crapting your pants somehow seems worse to me so why aren't they testing this stem cell therapy for IBD and even IBS.

Bottom line, I sure as heck hope this treatments works and they quickly apply it to all autoimmune diseases....I hope this will be our cure! The sooner, the better.

Fndcureforuc, please do write your congressional representatives about this. Maybe if enough people write to their congressmen, something good will happen which will help a lot of people (and harm no one).

Gsmall said...
Any news on this... What ever happened to it... Gees.. like these studies just fade away...

Athersys Multistem is currently on phase II of the clinical trials.

ATHX expects initial results from the study to be disclosed in Q2/14.

Source: www.scimitarequity.com/articles/athersys-athx-pfe-p2-completes-enrollment-ulcerative-colitis-trial-buy