Weight loss diets to prime UC?

While perusing the forums, I found this paper, courtesy of Old Mike. It's about the possibility of UC being a disease of energy deficiency. IF I'm interpreting this paper correctly, it seems to suggest that the colonic mucosa not being able to rebuild the mucus layer effectively is an expression of energy deficiency.

http://www.ncbi.nlm.nih.gov/pubmed/6106826

Please let me know if I am misinterpreting, there's some complex knowledge in there.

I ask because about two years ago, I embarked on crash diets and developed an eating disorder and the worst of it lasted about a year and a half. Then as I embarked on eating disorder recovery, a few months in I got a terrible infection in my colon. Then 8 months or so later, I get cellulitis, and the antibiotics I took led me to start having bloody diarrhea that eventually led to my UC diagnosis about two weeks ago.

I theorize that these sets of events each played a part in the progressive weakening of the mucus layer in my colon, with the year of crash diets and the severe episode of infectious colitis before I could recover setting me up for the eventual tipping point, which was the next course of antibiotics.

So my question: How many of you were on weight loss diets or any sort of diet for a long period of time or stayed hungry for a lengthy period of time (1 year +) and subsequently developed UC?

I'm just curious, I by no means am claiming anything with my post. Just interested to see if there's any correlation.

He is specifically talking in this case about,a oxidation problem with butyric acid.
It is suggested that failure of fatty-acid (n-butyrate) oxidation in UC is an expression of an energy-deficiency disease of the colonic mucosa. From what I can remember too much hydrogen sulfide can interfere with this process.

He is also looking at these cells after UC has already happened,remission or not, so many metabolic pathways perhaps are somewhat dysfunctional.

That is not to say that other forms perhaps of energy deficiency, such as no carbohydrates to feed the
bacteria that make butyric acid wont cause a problem, as does diversion colitis.
Or even not the proper amounts of threonine and other amino acids that make core mucins
you might consider a form of colon cell starvation,since they cant make enough or the right kind
of mucus. Once you get colitis you need more of these amino acids to build mucus,because many
are used by the immune system to build inflammatory molecules at the expense of making mucins.
So while you are making all these cytokines that are inflaming your colon, you might also be starving
the goblet cells,so you need to feed them.
Then if you are not making the normal amount or the right kind of mucus,then the bacteria can also starve.

Old Mike

Post Edited (Old Mike) : 8/4/2014 5:31:42 PM (GMT-6)

Interesting, I was diagonised after pregnancy. During pregnancy I had gestational diebetic. So I had restricted carb intake highly.

Thanks for sharing sweety5 and UC89. I've read that a large amount of people in the US are doing weight loss/dieting regimens at any point in time, so it might just be a coincidence if someone was doing something like that and got diagnosed. Everyone might have a different threshold for what it takes to set them over the edge, but maybe the weight loss thing could be something to consider.