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I knew it. Here comes the worm pill.

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Posted 10/28/2014 9:38 PM (GMT 0)
FYI. Not that worms work all that great on UC. Probiotic may comment on his multiple worm treatment

failures.

Old Mike

http://medicalxpress.com/news/2014-10-worm-protein-pill-inflammatory-disease.html

Other news,SOY and IBD.

http://medicalxpress.com/news/2014-10-scientists-key-factor-relationship-diet.html

 

Post Edited (Old Mike) : 10/28/2014 5:29:06 PM (GMT-6)

Posted 10/28/2014 10:26 PM (GMT 0)
Its about time they started developing a drug out of this research. Very excited for this. Would definitely be willing to go into this clinical trial
Posted 10/28/2014 10:48 PM (GMT 0)
If people think FMT is gross, I can't imagine how people feel about taking worms after looking at that picture, haha.
Posted 10/28/2014 11:24 PM (GMT 0)
This is great news IMO! Thanks, OM.
Posted 10/28/2014 11:58 PM (GMT 0)
Wow, both very interesting artices!
Posted 10/29/2014 12:17 AM (GMT 0)

Tunnelvisionary said...
If people think FMT is gross, I can't imagine how people feel about taking worms after looking at that picture, haha.

As you probably know, they avoid actually taking the worms by just taking protein isolates from the worms.

But honestly, if being infected by those worms would put my UC into remission for the first time, I eat them by the kg
Posted 10/29/2014 2:00 AM (GMT 0)

Marauder93 said...

Tunnelvisionary said...
If people think FMT is gross, I can't imagine how people feel about taking worms after looking at that picture, haha.

As you probably know, they avoid actually taking the worms by just taking protein isolates from the worms.

But honestly, if being infected by those worms would put my UC into remission for the first time, I eat them by the kg


Figured that out after I read the article, cuz I made that post as soon as I saw that terrifying picture hahaha.

Yeah, I hear you there, man.
Posted 10/29/2014 2:33 AM (GMT 0)

Marauder93 said...

Tunnelvisionary said...
If people think FMT is gross, I can't imagine how people feel about taking worms after looking at that picture, haha.

As you probably know, they avoid actually taking the worms by just taking protein isolates from the worms.

But honestly, if being infected by those worms would put my UC into remission for the first time, I eat them by the kg

You and me both.
Posted 10/29/2014 4:47 AM (GMT 0)
OM,

The second article says" Bioactive sphingolipids play fundamental roles in carcinogenesis via their ability to regulate programmed cell death pathways". Then I went and researched on Spingolipids. Based on wikipedia, there are set of disorders associated with sphingolipids metabolism and these disorders are sustantially high in Ashkenazy jews. UC is also high in Ashkenazy jews. Is there any connection? I mean is there is a possibility UC is the issue of metabolising sphingolipids :S.
Posted 10/29/2014 10:50 AM (GMT 0)
Sweety:

I really don't know anything about this subject,but here is the complete paper.

Perhaps someone on the site can comment,on you question.

Old Mike

http://www.jci.org/articles/view/74188

Posted 10/29/2014 4:00 PM (GMT 0)
Yeah OM, nothing spectacular from my worm attempts years back. The only one that seemed to dampen the UC a little (not remotely enough to justify the cost and it never put me in full remission) was TSO, and that was when a lightweight like me was taking double dose, and of course it is hideously expensive. (If insurance starts covering worms it could help more of course). Tried hookworms and just got violent side effects, watery D etc and no benefit to my UC. Tried human whipworms and even after trying several different protocols, got nothing but watery D and cramp side effects as my body kept eanting to purge them. My seasonal hay fever hiwever did drop way off with all the worm attemots and to this day years later seems much milder than it was before I became wormboy lol.

Worm pills may well get benefits without the vicious expelling side effects issue, for you guys and gals still wi the colons I hope this goes somewhere.
Posted 10/29/2014 7:18 PM (GMT 0)
Two interesting and promising articles. Thank you for posting. I'd sign up for trials of both.

I also noticed linked on the page this article
medicalxpress.com/news/2013-01-multiple-sclerosis-drug-day-colorectal.html#nRlv
"Perhaps the most significant aspect of this study is the therapeutic potential of fingolimod in the treatment of colitis-associated cancer," says Spiegel. "Since this drug is already approved for clinical use, we're hoping to initiate a clinical trial to study its efficacy in patients with CAC in combination with approved therapies."


Also mentioned in this paper www.nature.com/mi/journal/v7/n1/full/mi201373a.html "Finally, a new concept to target lymphocyte traffic in UC consists of the sphingosine-1-phosphate receptor agonist fingolimod (FTY-720).192 This substance induces retention of leukocytes in lymph nodes and thereby prevents their entry into the gut mucosa. Clinical data will have to demonstrate whether this substance has a role in IBD therapy"
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