FMT puts 7 out of 9 patients into remission at 2 weeks, and 5 out of 9 maintained remission. IBD

Fecal Microbial Transplant Effect on Clinical Outcomes and Fecal Microbiome in Active Crohn's Disease.

http://www.ncbi.nlm.nih.gov/pubmed/25647155

This could explain why some people with UC went into remission with FMT - they were misdiagnosed and really had Crohns.

7 out of 9 success rate has also been seen for FMT treatment of UC.

kiptyn said...
BruceN can you link to info showing FT success with UC?

Yes, here it is.

http://www.crohnsandcolitis.ca/site/c.dtJRL9NUJmL4H/b.9013357/

Below is the relevant passage:

In an earlier study, the McMaster researchers found that seven of eight UC patients responded to fecal transplants and six patients remained well one year following treatment. “We’re seeing success rates of 80 to 90 per cent. This kind of clinical trial is absolutely essential for a new treatment to become a standard of care,” says Dr. Surette, who holds a Tier 1 Canada Research Chair in Interdisciplinary Microbiome Research and is well known for his research on the complex relationships between bacteria and disease.

The very interesting thing about this initial study was that only certain donors were highly effective. The researchers are now beginning to isolate the bacteria from that donor and trying to culture them.

Glad we are seeing that scientists are still studying FMT for IBD. I really do think the microbiome will be shown to play a key factor in the pathogenesis of IBD. I think it's also important to keep in mind all the null results from FMT/IBD studies as well, though having a positive result is a good thing. FMT is something I want to try when there aren't any more options left.

Guardian7 said...
Crohn's is the more severe "version" of UC if we are being technical, so I don't see why it shouldn't apply to IBD in general. The inflammation can be anywhere from the mouth to the anus. This is one of the reasons surgery should be weighed carefully... a former doc of mine said it can difficult to rule out crohn's in those with UC pathology.

Being technical, it is IBD with more extensive location and deeper lesions. However it is too simplistic to say UC is Crohns lite. While misdiagnosis is common, they are distinct diseases.

Anitatou said...
I just recently had FMT in December 2014 and went into remission. No active disease at all. it is very effective!
I posted a separate thread today asking whether mucus in stool is normal - I have normal BM and no diarroeah, but I have mucus? just wondering has this happened to anyone else post treatment or in remission.
I recently started taking Zoloft for depression so hoping this has not kicked it off.

Do you still do SCD after the FMT or can you eat anything now?

Because one recent pediatric trial for Crohns, using a nasal-gastric route, managed to treat the small intestine. Very small sample, but great remission rate.

Notably, the same team reported no result with the 4 UC patients they treated.

The sudden change is people always hope. I hope too. I think thee studies, even the ones without positive results, are going to lead to advanced and individualized probiotic (or other gut microbe focused) therapies.

I think it's great that someone is doing these studies but 9 people is not enough to determine much of anything. besides the point they were only followed for 12 weeks. I'd like to see a longer study with a larger group of more diverse people.

Tunnelvisionary said...

DBwithUC said...

Guardian7 said...
Crohn's is the more severe "version" of UC if we are being technical, so I don't see why it shouldn't apply to IBD in general. The inflammation can be anywhere from the mouth to the anus. This is one of the reasons surgery should be weighed carefully... a former doc of mine said it can difficult to rule out crohn's in those with UC pathology.

Being technical, it is IBD with more extensive location and deeper lesions. However it is too simplistic to say UC is Crohns lite. While misdiagnosis is common, they are distinct diseases.

Agreed, Crohn's seems to have an entirely different pathology about it so I think it's a mistake to just characterize it as severe UC.

Anyway, not that it's unwelcome, but what is with all the sudden praise and these positive FMT studies? As I recall, just a few months ago there were a few studies showing dismal results of FMT within IBD and plenty of stories of users here not succeeding with it.

I wonder why the sudden change?

There is no sudden change. Change is always slow, but FMT is picking up momentum in the IBD arena because of the burgeoning research on the microbiome. Gut health seems to be a key indicator of overall health, and a very good predictor in autoimmunity.

As far as UC is concerned, people are fed up with more of the same existing therapies in the pipeline. Biologics, 5asa derivations, new steroidal treatments... I honestly think it's a joke. In the pharmaceutical realm, we aren't expected to see squat in terms of therapies that address the root cause.

FMT is actually quite a popular therapy in the veterinary field and it has been around since the 4th century. Only now is the science backing up its use for IBD.

"Fecal transplant was first documented in 4th century China, known as “yellow soup”.
It has been used for over 100 years in veterinary medicine, and has been used regularly for decades in many countries as the first line of defense, or treatment of choice, for C. diff. It is customary in many areas of the world for a newborn infant to receive a tiny amount of the mother’s stool by mouth, thought to provide immediate population of good bacteria in the baby’s colon, thereby jump-starting the baby’s immune system."

For Nothing L:
Born in a third world country (Srilanka), Its true that people living in country side in third world country is exposed to more organic wastes than western people. But I guess if you live in city area it almost same as western living everything paved and piped, no animals etc.

I guess people around the world has different hygine practices. There is no right or wrong. There are things my grand parents would find it unhygine in western life style. For example..

1. Having shower and toilet together, inside the home. Because in srilankan villages they always built toilets outside.
2. Eating red meat every day. Most people from older generations are vegetarian in Srilanka and even now red meat is an occational food.
3. Taking dirty shoes inside home.
4. Eating raw food. They even cook our vegetables thoughly before eating.
5. Sitting on a toilet seat. Srilankan use the squatting pans etc etc.

I'm not sure what makes you think that using toilet tissue is hygine than washing with water. And how do you know they dont wash their hands poperly.

I beleive the reason why ibd is less in common in thrird world countries is most of them are closer to equator, so stable weather and plenty of sun light
( exposed variety of godd and bad micombes) . Simple diet, boiled food, milk and water, more laughter, breast feeding, enough sleep.

The reason why its now increasing is more stress, lots of artificial light, changed diet and less excersise. Nothing to do with toilet paper.

Guardian7 said...

As far as UC is concerned, people are fed up with more of the same existing therapies in the pipeline. Biologics, 5asa derivations, new steroidal treatments... I honestly think it's a joke. In the pharmaceutical realm, we aren't expected to see squat in terms of therapies that address the root cause.

FMT is actually quite a popular therapy in the veterinary field and it has been around since the 4th century. Only now is the science backing up its use for IBD.

I started having UC symptoms after a bout with antibiotics, so i'll never not feel there is a really close connection between the microbiome and IBD, at least in my experience.

I agree that the current options right now look pretty dismal. Once 5-asa's stop working, the jump up the drug ladder is insane. Dealing with insurance and Humira being $2,000 a dose? If my new insurance doesn't come through, the next option for me is surgery since it won't cover any of the other biologics. I've been on mesalamines since I was diagnosed and half the time since then has been spent fighting off a flare up.

Would love to at least be able to get by for at least another 5 years with my colon, I really feel we'll have a lot more solid options with Celgene's new drug and a lot more FMT/probiotic research.

I wrote off FMT for UC a while back, but if the research keeps showing positive indications even for at least some subgroups of those with IBD, I would absolutely want to see if that could get me into a solid remission. Very much hope FMT in some way, shape, or form can become the answer.