OM, you know, there is a hypothesis saying Crohn's is caused by innate immunodeficiency. Some intracellular bacteria(AIEC, mycobacterium...) takes the advantage of this and crohn's patients can't clear the intracellular infection but immune system keeps trying... That causes an autoinflammatory condition(Crohn's).
You can google "crohn's and innate immunodeficiency".
SSI vaccine trial, John Herman Taylor's MAP vaccine... are based on this hypothesis.
I've copied an article written by SSI vaccine people into a word document back when I've read it. The link doesn't work now so I copy paste it here:
"SSIs and Immune-related Disease
Inflammation is part of the normal healthy biological response to harmful stimuli, such as pathogens (i.e., infectious agents that causes disease or illness to their host, often referred to as ‘germs’), damaged cells, or irritants. Acute inflammation is the initial response made by the body to attempt to protect itself by removing the harmful stimuli and initiating the healing process. However, sometimes the process can become deregulated, leading to a prolonged response, known as chronic inflammation. In this case, there is a progressive shift in the type of cells present at the site of inflammation, with ongoing simultaneous destruction and healing of the tissue, leading to the symptoms that characterize a number of diseases, such as inflammatory bowel disease and rheumatoid arthritis.
Recent research in the field has led to the hypothesis that Crohn’s disease may be caused, at least in part, by an inability of a particular type of white blood cell, the macrophage, to effectively clear damaged or infected cells (Gersemann et al. Journal of Internal Medicine 2012, 271(5):421-428, Korzenik et al. Digestive Diseases and Sciences 2000, 45(6):1121-1129, Marks et al. Clinical Reviews in Allergy & Immunology 2010, 38(1):20-31). According to this hypothesis, if damaged or infected cells are not efficiently removed by macrophages, they become necrotic (i.e., die prematurely due to injury or disease) and release their contents into the surrounding tissue and/or blood vessels. The body then responds by generating an adaptive immune response against these cellular components, resulting in an autoimmune response, i.e., a response against “self”, resulting in chronic inflammation in the affected tissue(s).
In order to break this self-sustaining cycle and effectively treat the underlying cause of Crohn’s disease, the source of this chronic inflammation must be cleared. Qu Biologics is investigating whether this can be achieved by treating with SSIs, Qu Biologics’ proprietary immunomodulation therapy platform. Qu Biologics has demonstrated that SSIs initiate an innate immune response in the organ/tissue in which the bacterial species commonly causes infection. For example, an SSI derived from a bacteria commonly found in the human gut stimulates an innate immune response in the colon and gastrointestinal tract, potentially resulting in recruitment of new macrophages to the colon to clear the self-antigen that is triggering the chronic inflammatory response. Qu Biologics hypothesizes that once this underlying source of inflammation is cleared, the symptoms characteristic of the autoimmune disease being treated may potentially resolve.
In the course of a normal immune response, key immune cells, called macrophages (green spiked cells) recognize and eliminate infected and/or damaged cells. These infected or damaged cells normally undergo a type of programmed cell death called apoptosis (pink round cells). Macrophages ingest these infected or damaged cells in a process called phagocytosis. This leads to the production of signalling molecules, called anti-inflammatory cytokines, which tell the body that the threat has been neutralized and that everything is OK.
It is hypothesized that in certain individuals, the normal immune response described above has been compromised, and the macrophages (orange spiky cells) are unable to function efficiently to ingest and eliminate the infected and/or damaged cells undergoing apoptosis (pink round cells). These residual cells then undergo an abnormal cell death process known as necrosis (white and pink round cells), releasing their cellular components (small dark pink spots) into the body. These components are then recognized by the macrophages as “intruders”. As a result, the macrophages release signalling molecules, called pro-inflammatory cytokines, which alert
the body that there is a threat and so the body mounts an immune response against self, known as an autoimmune reaction. Other immune cells known as dendritic cells (specific immune cells whose function is to process antigen material and present it to other immune cells; light blue) and T cells (a type of white blood cell known as lymphocytes, that play a central role in cell-mediated immunity; dark blue) are also involved."
Can you think of any relation between RIT and immunodeficiency hypothesis?
Post Edited (xy123) : 6/20/2015 12:04:22 PM (GMT-6)