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Pfizer Reports Favorable Results on Oral Tofacitinib (Xeljanz) for Ulcerative Colitis

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Ulcerative Colitis
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Posted 9/23/2015 11:25 AM (GMT 0)
ibdnewstoday.com/2015/09/22/pfizer-reports-favorable-top-line-results-for-oral-tofacitinib-for-ulcerative-colitis/
Posted 9/23/2015 12:39 PM (GMT 0)

The drug is an oral janus kinase inhibitor.

http://www.nejm.org/doi/full/10.1056/NEJMoa1112168

and what do you know so is curcumin.

Old Mike

Posted 9/23/2015 1:26 PM (GMT 0)
Believe me I've been watching this like a hawk, this looks like it might be that magic bullet. I remember reading that the EMA shot it down some time ago due to adverse effects but at this point all the other info I've gathered looks favorable. Didn't know you could buy curcumin in tablet form, intriguing, might have to shop around on amazon later on.
Posted 9/23/2015 1:36 PM (GMT 0)
I think the expectation is that trials will be done by end of 2016, application sent out in 2017 and drug to market by late 2017/early 2018. Probably the next big one to come out
Posted 9/23/2015 1:37 PM (GMT 0)
Old Mike

I so appreciate your keeping up with the science behind the RX meds. This morning I heated up my 95% curcumin in a little chicken broth. You are correct it does not have a taste at all. This may be my new way of taking curcumin.
Posted 9/23/2015 1:50 PM (GMT 0)
Just search janus kinase curcumin.

Here is a bit.

https://books.google.com/books?id=P2ykHQi6RvMC&pg=PA327&lpg=PA327&dq=janus+kinase+curcumin&source=bl&ots=OUQ_e90iS4&sig=k2lchUvY0seht0a-k05uI_z81eg&hl=en&sa=X&ved=0CEQQ6AEwBmoVChMIqdjK56eNyAIVAx0-Ch2XugoR#v=onepage&q=janus%20kinase%20curcumin&f=false

Also I heated 1300mg of curcumin in a little water in the microwave, in water it does have some taste but

not too bad.

I suppose when in soup or something like that the mild taste is covered up.

Old Mike

Posted 9/23/2015 2:00 PM (GMT 0)
Something to control your UC and your blood sugar at the same time? Sounds too good to be true to me, but I hope it will be. I've seen a lot of "magic bullets" come and go. People waited years for Entyvio to be approved, certain it would make them well. So far, I'm not impressed by the number of real success stories I'm seeing here. I've learned to reserve my enthusiasm a bit.
Posted 9/23/2015 2:19 PM (GMT 0)
For what it's worth I'm on Entyvio and after close to 4-5 months on and off of Uceris I've been steroid free since week 6-7 of treatment. Didn't have much hope as response after induction dosing didn't look credible per studies however I'm pleasantly surprised and hoping I'll hold.

Response and remission percentages look much more promising with Xeljanz when compared with Entyvio (Response of 10 mg @ 8 weeks=61%, remission of 10 mg @ 8 week=48%), I'll remain hopeful :)
Posted 9/23/2015 4:12 PM (GMT 0)

Marauder93 said...
"I think the expectation is that trials will be done by end of 2016, application sent out in 2017 and drug to market by late 2017/early 2018. Probably the next big one to come out"

The Ab field is producing a lot of products but it's a long wait at the end of the pipeline. Those of us on Ab therapies can mark our calendars and do our best to hang on to our colons until the magic bullets arrive.

Posted 9/23/2015 4:30 PM (GMT 0)
My GI said she sent a lot of people for this trail and had none with response. I guess it's that same group of non-responders who don't respond to anything. You have to consider that in order to be needing to go into this trial, you probably failed everything else. in my case, I was a non-responder to all of the other medications, so it's likely this wouldn't work for me either. I hope it works for other people. I really wish someone would try to figure out why the non-responders don't respond to anything, what we have, and whether there are any treatment options besides surgery.
Posted 9/23/2015 5:02 PM (GMT 0)
Here is more on inhibitors and how they work.

I do notice that you are more prone to infection as a side effect,at least with the drugs.

Why there are people who do not respond well to anything, wish I knew.

Old Mike

what goes on

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129380/

janus kinase activated by you guessed it hydrogen peroxide,thats at least one way

now I have to think about taking boiled/cooked curcumin and also taking NAC

http://www.ncbi.nlm.nih.gov/pubmed/9843726

 

Posted 9/23/2015 5:21 PM (GMT 0)
Old Mike, how much are you heating the 1300mg of curcumin, and is it just pure curcumin that you are using?
Posted 9/23/2015 5:36 PM (GMT 0)
Just dumping 2 capsules into less than 1/2 cup of water, heat 2 minutes in microwave covered of course.
Let sit about 10 minutes to cool.
Or add it to soup,it also dissolves better with some fat.
Using NOW brand curcumin.
OM
Posted 9/23/2015 7:09 PM (GMT 0)

Old Mike said...
Just dumping 2 capsules into less than 1/2 cup of water, heat 2 minutes in microwave covered of course.
Let sit about 10 minutes to cool.
Or add it to soup,it also dissolves better with some fat.
Using NOW brand curcumin.
OM

i ve been lurking for a bit. my gf got crohns. whats your rational behind what you are taking :

R Lipoic Acid, NAC, Sodium Butyrate, Selenium, Vitamin D,B2 to insure reduced glutathione.

you think that would work for crohns as well?
Posted 9/23/2015 7:17 PM (GMT 0)
R Lipoic Acid, NAC, Sodium Butyrate, Selenium, Vitamin D,B2 to insure reduced glutathione
This stuff is for UC to reduce reactive oxygen species/ROS, probably not a good idea for crohns.
Reducing ROS in crohns may also reduce immune system killing power so if crohns is caused by
MAP or made worse by AIEC,this could by counter productive.

Old Mike
Posted 9/24/2015 3:05 PM (GMT 0)
My doctor talked about starting me on xeljanz after my surgery. I looked up some RA reviews and it seems to have some side effects that are pretty common including increased cholesterol, severe/painful heartburn, and hotflashes. Some reviewers are taking additional meds for the high cholesterol and heartburn. I am really against taking a med that will then cause me to take another med, especially cholestorl drugs, I am totally against those.

I am not thrilled about the possiblity of taking this.
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