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Itchy Entyvio

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Ulcerative Colitis
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Posted 1/8/2016 12:37 AM (GMT 0)
Had my 4th infusion on December 22nd and have been really happy with how it's been going. I get premedicated with Benadryl, never had any issues.

However since my last infusion I have been getting increasingly itchy...I live in Florida so it's not dry skin from winter. No hives or bumps. And I'm down to 2.5mg of prednisone...which I think may be why I'm itching this time and not in the past.

Curious if anyone else has had this. I asked on the Entyvio Warriors page but haven't had any replies yet. I'm just concerned this may end up being an allergy and that I'll have to discontinue, which would be heartbreaking.
Posted 1/8/2016 4:34 PM (GMT 0)
Yes, definitely very itchy and some rash after 3rd infusion. It lasted for weeks and seems to get worse with each dose. Not terrible just uncomfortable. Tapering Pred still after several months but at low dose like you & suspect it doesn't help. Took Benadryl. Did you try that?

Game plan: So at 4th infusion doing a bolus of solumedrol first, and then a few days of high dose prednisone. Then back to low dose to finish Pred taper.

I tried to join entyvio Warriors on Facebook with a request to join group. No reply. Can you explain how that works?
Thanks.
Posted 1/8/2016 10:08 PM (GMT 0)
I've been itchy a lot of the time on it on upper back, chest and upper arms. The itching wore off about 3 weeks after #3 . Had #4 today and feel the odd itch. It hasn't ever broken out to a rash yet. Having always had sensitive skin anyway I'm used to a pretty strict regime of not scratching, non-perfumed washing powder and washing only with tiny amounts of soap. I have put a basic aloe vera gel on it sometimes. So far so good.

I have no idea what the itching is caused by but I have seen others report it, trying not to worry about it. I saw that the mixture contains histidine so I don't know if this is a factor. Today though I also got wondering as I noticed my MPV in blood count has raised and I came across research that this is linked to urticaria www.sciencedirect.com/science/article/pii/S2352241014000097, not that I'm any the wiser for finding that out...
Posted 1/9/2016 12:40 AM (GMT 0)
Thanx guys for the replies, glad I'm not the only one but also wish it didn't seem like this will be the norm. I do get solumedrol as a premed. I haven't gone out and bought Benadryl yet but that wil be the next step. The itching is worse today: scalp, face, arms, ugh!!

And as far as the entyvio Warriors, after the get the request one of the moderators messaged me a few days later to ask if I was on the medicine, I replied and then was approved to join. I'd say try to join again, keep a look out in your "other" folder of your Facebook inbox. It's an OK group, but lots of stupid questions that are asked over and over....I much rather come to this forum for real and useful information. But sometimes it is nice having faces to match to names.
Posted 1/9/2016 1:23 PM (GMT 0)
I used to have itchy reaction to Remicade but it was only during the infusion. By the time the infusion was done, it was gone. And the itch was not all over, it was in a small area. Mary
Posted 3/5/2016 7:36 PM (GMT 0)
Just wanted to report that infusion #5 went well. Had solumedrol by IV right before Entyvio. No itching or rashes. Fingers crossed!
Posted 3/5/2016 10:57 PM (GMT 0)
I have been on Entyvio for over a year now . Always get Benadryl before each in fusion No problems with itching
I did join Entyvios. Warriors found it to be silly , same questions every day and constant pictures of people getting their ln fusions
I like this forum better turn
Posted 3/7/2016 10:07 PM (GMT 0)
I found Warriors to be a bit discouraging, too. I am very loyal to this forum, having been here on and off for 7 years, but think it's very uniquely helpful and supportive. Part of the issue in Warriors, I believe, is far more Crohn's diagnosis than UC and from what I understand Entyvio is working better for UC, so it's more helpful to have a specific community. And yes, also a bit silly.

For OP, no itchiness I've noticed. I've been on it for about 8 months now.
Posted 3/8/2016 10:14 PM (GMT 0)
just had #5, haven't had the usual itchyness but am feeling a lot more tired this time
Posted 3/9/2016 6:19 AM (GMT 0)
Also had much more fatigue with infusion #5. Was flat out for two days afterward.... Never had that before.

Decided not to view Entyvio Warriors. Similar reasons. Loyal to our forum. :)
Posted 10/10/2016 4:36 PM (GMT 0)
Has anyone had a severe rash on their feet? I've been on Entyvio for 4 months and just discovered this rash last week. My last infusion was 9/29. I had been on a high dose of prednisone because of a flare of my UC. Currently I'm on 10mg and hoping to taper down. So far, Entyvio is helping me, UC seems to be calm. My main problem has been cramps, no cramps so far on Entyvio. I've been on Asacol, 6MP, Remicade, they all worked briefly then quit. I am praying that Entyvio is the answer, if not, then it's surgery.
Posted 10/10/2016 5:44 PM (GMT 0)
I'd let your gastroenterologist know asap about the rash you've encountered. We're more predisposed to skin rashes while on biologics as they suppress the immune system. The rash could be nothing, or it could be a concern. I always defer to doctors on that point! Good luck.
Posted 10/10/2016 10:19 PM (GMT 0)
I have called him, unfortunately he is currently on vacation in Italy. I'm concerned about the interaction that Benadryl would have with other meds.
Posted 10/10/2016 10:23 PM (GMT 0)
An antihistamine like benadryl or claritin is fine, it might help.
Posted 10/29/2016 3:01 PM (GMT 0)
Benadryl worked on my rash. Entyvio is working for me!!!! Starting Nov. 1, I am tapering down on my prednisone, 1mg per month.
Posted 7/21/2018 11:33 PM (GMT 0)
I have been on Entyvio for a year now. Wasn't completely doing the job so they are giving to me once a month. Now I have started itching as of the third monthly infusion. The drug is working beautifully now but every two months it helped but not completely and then all the steroids are making my life miserable! Bruises everywhere so can now taper off of them I hope. But you are saying that when you get the rash that Benadryl helps?
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