Lialda question

I am switching from Asacol HD to Lialda. The doctor said I can take all 4 tablets once a day or split it into 2 doses of 2 tablets each. Right now I am doing 2 tablets 2x/day but wanted to know your experiences with this. I have seen in the different signatures here that people do both ways. What are the pros (other than convenience of once a day) and cons of each way?

I opted for twice/day because the reason I am switching is because I often saw whole Asacol tablets and I worry that if I have a similar issue with Lialda I could pass all 4 at one time.

Thanks in advance for your thoughts about this!

I always took all 4 in the morning. I understand the general idea of taking pills at different times of day, so they arrive and deliver medication at different times. However, I'm not sure how much (if any) difference the time you take the pills really makes as your digestive system moves things along at variable rates. Regardless of when you took them, those pills can be closely grouped together or spaced far apart. The ileocecal valve keeps things in the small intestine for a while, before allowing access to the large intestine. They might be grouped closely together when entering the large intestine. There's also many sharp bends and other valves between segments of the large intestine. Infact, I believe Quincy said her colonoscopy showed a pill hung up somewhere (despite the deluge of prep) lol.

The only real way to know, is try it both ways and see if you experience any difference. So, consider me a skeptic on split lialda doses. It certainly does no harm.

I take all 4 at once

If I take them in afternoon or evening, I have trouble sleeping and restless leg. I do all in morning.

Good plan to try twice a day then once a day and see which works better for you.
q