www.ncbi.nlm.nih.gov/pubmed/1882577313 out of 19 sounds good - but this is very small sample
also, maybe some options for other enemas:
www.ncbi.nlm.nih.gov/pmc/articles/PMC3091152/"medications like tacrolimus suppositories and tacrolimus, ecabet sodium, arsenic, lidocaine, rebamipide and Ridogrel® enemas have only demonstrated clinical efficacy in
open-labelled studies. In those novel agents that have undergone randomised studies, butyrate, cyclosporine and nicotine enemas did not demonstrate efficacy above that observed for placebo, while, despite impressive evidence for epidermal growth factor enemas, there has only been a single small study."
Also, perhaps you should see about
having a suppository compounded instead of an enema:
"Two recent studies have started to investigate the efficacy of rectal tacrolimus in resistant DC. In the first, eight patients with inflammation to a maximum of 30 cm from the anus were included. All patients had demonstrated disease resistant to numerous medications both standard and experimental.[45] Following 4 weeks of topical tacrolimus, 75% (6/8) of patients achieved clinical remission with oral corticosteroids ceased in the majority of patients. The second study examined the use of topical tacrolimus in 19 patients with resistant DC. Twelve patients received tarcolimus suppositories and seven tacrolimus enemas. Clinical and histological improvement was observed in 10/12 patients treated with tacrolimus suppositories, but there was
no significant benefit in the majority of patient receiving the tacrolimus enemas,[46] potentially due to, as the authors suggested, the lower concentration of tacrolimus at the mucosal surface with the enema preparation. No major side effects were reported in either of the studies and the preparations were well tolerated. To date no randomized placebo controlled trials have been undertaken."
www.medscape.com/viewarticle/737625_2Post Edited (DBwithUC) : 6/30/2015 7:20:18 AM (GMT-6)