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Questions, some about Uceris

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Ulcerative Colitis
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Posted 2/22/2017 8:35 PM (GMT 0)
I have been off of Uceris for 6 days, and started having a bit of d today. I had been almost back to normal for two weeks before going off of it. I had been on Uceris for almost a month after 1 week on solumedrol, and 2 weeks on Prednisone. My two questions are, how long would you expect flaring back up to start if it is related to dropping the Uceris, and can Uceris cause hypoglycemia symptoms? I was experiencing the hypoglycemia symptoms 1-2 hours after eating. The first day after dropping the uceris, I crashed really badly. Since then, however, I have not had really any problems with it at all.

The other question I have relates to stepping up from Messalamine type drugs to immune suppressing. My doctor was already talking about doing that if what I am on doesn't kick it. When I saw him yesterday, he was very happy with how I am doing, and said he didn't think I needed it. I know I waited longer than I should have the first time around before going to the doctor, so I am trying to figure out the new normal. Is it normal to be talking next stage drugs so quickly? I was diagnosed January 3. Also, how much diarrhea merits calling my doctor? I don't really want to go on next stage, and it seems like people have symptoms for months and years on end anyways. Also, why do we get sick if this disease means our white blood cell count is elevated and our immune system is ramped up? Thanks!
Posted 2/23/2017 1:49 AM (GMT 0)
Uceris, solumedrol, and prednisone are also known as glucocorticoids due to their remarkable ability to cause our blood sugar to spike to very high levels of sugar (glucose). Having high levels of sugar within us for long periods of time can damage our pancreas's ability to produce insulin which normally regulates our blood sugar levels. That results in type ii diabetes and other blood sugar management problems.

Everyone has a very different path with their UC treatment, some have a very mild case that enables them to maintain on just the mild mesalamines for decades, some need stronger meds. Some have a leisurely climb up the medication ladder over a series of years, others rush up that ladder at a fireman's pace, and some don't respond to any uc treatment and surgery quickly finds them. There's absolutely no knowing what you'll ultimately need to control your UC or how fast you'll go up the ladder. UC prognosis can be very unpredictable, especially within the first 5 years after diagnosis.

A single day's worth of diarrhea is nothing to worry about. If our symptoms are consistently and persistently worse for 4-5 days then contact your gasteroenterologist. You always want a stool test to rule out possible pathogenic causes to your worsened symptoms like c diff. Your doctor might want to see what's going on with a flexible- sigmodscopy with biopsies. Stronger meds might be discussed.

Any signs of blood? Flares usually involve blood on tp when wiping? We can get salmonella or food poisoning like anyone else can...

Nobody really knows what causes UC or what out bodies are doing or why. Uc is either autoimmune or at least an immune deficiency. Our inmune system is attacking something endlessly, some say it might be a hyper-sensativity to a common bacteria, or perhaps a Johne's disease-like tuberculosis bacteria (like in cattle) that's antibiotic-resistent and immune-resistent and we can't eliminate it on our own. Regardless, our WBC are elevated as our immune system is attacking something...
Posted 2/23/2017 2:12 AM (GMT 0)
Thank you ipoop. I thought I had read somewhere about the blood sugar issues in regards to UC, but I didn't find anything when I searched in relation to Uceris. I couldn't remember what to look under. I know the labs in from when I was in the hospital said my glucose was high all but one day they took my labs, but I thought it was just from the glucose in the IV. Maybe that just doesn't help? I have no diabetes in my family really, but I think if I end up on steroids in the future, I will need to let them know. I actually called and asked to drop the Uceris because I suspected that it was causing me the blood sugar problems.

I also appreciate the guideline. Its helpful since they don't give us a handbook for all the details.
Posted 2/23/2017 3:44 AM (GMT 0)
imo, until you've tried rectal meds, there should be zero talk of stepping up from Messalamine type drugs to immune suppressing -
Posted 3/15/2017 4:19 PM (GMT 0)
has anyone in here tried Proctocort or Uceris Rectal meds. My doctor has mentioned to me trying Uceris but I just looked into Proctocort as well. If my diet doesn't help straighten me out with Canasa in the next two weeks, I will be looking to bring this up for a decision with my doc.
Posted 3/16/2017 2:44 AM (GMT 0)
Proctocort is a Hydrocortisone (a type of steroid) suppository. Uceris is a buedesone (a type of steroid) available in foam or delayed release, oral pill. Of those two, uceris covers the most area.
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