HLA B27 gene linked to autoimmune response?

Hi everyone,
I have been reading up on the hla b26 gene & it's high link to autoimmune conditions. Wondered if anyone has been tested for it & if they were positive?

Sorry typo hla b27!
Most people that have UC & develop joint related issues are likely to have the gene.
Usually your GI or who sees you for your joint symptoms would test you.

Thanks for the response, do you find the symptoms occur when flaring or are they are not related? I'm trying to figure out how limit the joint flares & only a month ago thought to try a diff diet.
Also trying to be more active to strengthen muscle around the joints hopefully.
With this disease if it's not one thing it's another 😞

Your right sometimes it holds no bearing at all. I have no family history of IBD at all. After a course of antibiotics bk to bk & food poisoning is what triggered the disease. 4 years later the other conditions followed.
It is interesting that this gene in particular is highly linked to extra manifestations. All I immune related.
In the U.K. The statistics are really high in those found experiencing joint & eye related issues with IBD & carry this gene.

My rheumatologist tested me for it. I am negative. I still have UC and spondylarthropy. My rheum expressed a similar view to UC prisoner's but was willing to test for it.

It's mildly complicated, in that while I've been in technical remission for UC for 5 years now, even in remission I had watery stools (1 a day) and abdominal pain. My joint pain started 3 years ago and as I was afraid of Humira I decided to start SCD to see if I could get to a better UC remission and if doing so would help my joint pain.

For me it has worked. The more closely I follow SCD, the more solid my stools and the less joint pain or stiffness I have. My two major arthritis flares since starting SCD were both when I decided that the SCD effects were all in my head and I was going to eat more normally. In each case, my joint pain was bad enough that I had to take to my bed and miss several days of work. My watery stools returned as well. All of that said, SCD is hard to follow when out and about (even with the best will in the world) and I find it has definitely had two steps forward one step back phases. Also, I strongly believe that while it helps me manage symptoms, it's neither a panacea nor a "cure". It's just another tool to use. And other things seem to help me too, but I've never explored them thoroughly. Wild Oregano oil, hard cheese and MSG also seem to help me have more formed stools. I can even deviate mildly from SCD if I use WOO or have food with MSG.

My rheum says in my case the UC and joint pain seem to correlate but that's not always what he sees. I do remind him I technically had joint pain while in remission too, but I didn't consider my remission solid enough (pun intended) so I see a correlation where he might not.

Mia....how were you diagnosed with reactive seronegative arthritis?

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Through blood testing?

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WOO is Wild Oregano Oil. It's a known anti-bacterial treatment that targets gram negative bacteria. I use it sparingly as it seems to help a lot and I assume if it works well it probably has unexpected side effects too. You take 4-5 drops in water 2-3 times a day. If it will help you you'll know very quickly (within a week).

MSG is our friend from Chinese restaurants, monosodium glutamate. MSG heavy meals agree with my gut. I've never looked into why, but probably should. I assume it feeds some beneficial bacteria but it's probably more complicated than that.