Itchy skin and mesalamine

I've been on Canasa for 10 years and on Lialda for 1 full year now. Recently my skin has gotten itchy. I've been popping Benedryl to help now and then but I'm also on hypertension meds so don't want to go crazy with Benedryl. I'm wondering if since I take 4 Lialda a day and use 1 Canasa each night if this is mesalamine overload and possibly causing the itchiness. I don't see a rash. Just feel itchy.

Anyone else experiencing this?

Thank you for your thoughts on this Quincy. I thought about the detergent thing and just said to husband I may need to buy some fragrance free stuff. The nuts may be the culprit as I recently started eating unsalted cashews that I bought for my husband. May need to stop them and see. I never knew that BP meds can cause itchiness. In February I was put on Clonidine, Amlodapine, Valsartan and Hydrochlorithyazide (Exforge HCT) for my stage 4 hypertension. I'm also on Protonix for GERD. As well as the Lialda and Canasa.
I try to space everything out so that I'm not taking them all at same time.
The stress thing has definitely been a factor though for the last 3 months as my husband took sick and we've spent last 3 months back and forth to hospitals and specialists and having tests and procedures for him. Very stressful. So, it could be that or everything combined!!!
I'm thinking I just may be using Benedryl for awhile then.

Yes I've used Canasa since 2007 each night. I was originally diagnosed with Ulcerative Proctitis back then and had constant bleeding in the stool. My gastro doctor sent me to a proctologist who diagnosed me and put me on the Canasa. My gastro did a colonoscopy and told me it looked like a war zone up there and prescribed Lialda. My primary shortly after prescribed Cipro for a bladder infection and the Cipro amazingly stopped the bleeding. I stopped the Lialda and was symptom free for about 8 years but continued the Canasa because my doctor said to continue for maintenance. Then in 2015 I came down with the Shingles and right after that developed symptoms of what I thought was a Proctitis flare. After my gastro doctor tried to control it with Prednisone and cortifoam I wound up having another colonoscopy and was diagnosed with moderate to severe Ulcerative Colitis with 25 cm of ulceration in sigmoid colon. My gastro doctor said when he did the scope he saw that the previous Proctitis ulceration had completely cleared up from using the Canasa all those years. So he said since my Body had done so well on the rectal Mesalamine that he felt the oral would be well tolerated for my UC in the sigmoid so started me on thE Lialda at 2 per day then upped it to 4 per day with the Canasa continued too. So, it seems no problems with prolonged use. I do now also see a Nephrologist on a regular basis to monitor the effects on my kidneys and all is well.