hey there- same thing happened with me- did great the first 3 infusions, then 3 weeks after the 3rd one I started to flare. Called my GI doc, freaking out- he told me I was likely making anti-bodies to it, & we upped my Imuran. I don't think you can get Remicade on a 4 week basis indefinitely- it's a pretty heavy duty drug. But I would continue to take my other meds if I were you- once you make anti-bodies to Remicade, it won't work no matter how often you go. An immune suppressor is supposedly key to take while on the Remicade. I just had an infusion this past Monday & am doing fine again. How long, is the $20,000 question.... good luck!