Morning worse versus afternoon?

Hello,

Currently still in the middle of a flare. Hoping this entyvio does the trick. finishing my last loading dosage on Friday and I've felt some symptom increases already which has me hopeful.

One thing I've noticed during the duration of my flare, especially on these last few months is how much worse the morning is compared to the afternoon.

I'll wake up at 5-6am and go before getting in the shower. typically ill go again about an hour later as I leave for work. usually the commute leads to a lot of urgency and typically me hustling to get to downtown, into the parking garage, then just shy of running to my office to get to the bathroom. i've started to go in much earlier because traffic is less and my office is much emptier.

i will typically go 3-4 times before 11am and then once when I get home at around 5pm and maybe once before I go to bed. For a week stretch in between the Humira and Entyvio, I would wake up once or twice during the night to go, but that has since stopped.

Anyone have a clue why I go 3-4 times in a span of 5-6 hours but then only go 1-2 times for the other 18-19 hours? i typically eat a light breakfast and eat nothing before I go to bed.

Hi Nourse,

Unfortunately my experiment with Humira didnt go well. There wasnt one point that I felt any relief so it was a massive failure.

It's a shame that it didnt work. They sent the shots right to my house and I gave them to myself. Plus each shot was $5. It couldnt have been easier so I was bummed when it didnt work.

I wish you the best of luck with it. Seems like it works for a lot of people, I just wasnt lucky enough.

Mornings have always been the worst for me to. That being said, I know I'm really bad when I have to get up in the middle of the night to go. I don't know if it's related to hormonal fluctuations or getting up and everything "getting started" again. If something in the poo flora is making us sick, it stands to reason this will be the worst in the morning.

DBwithUC said...
Mornings are worse for most. I think it relates to dinural cycles, as well as the timing of meals the previous day. I would always have 3-4 bm before getting out of the house. but was usually good during the work day.

This was my pattern during the flare, too. All would have a lot of mucus and some blood.

BUT after the meds began working and healing started I developed constipation, and several times went 3-4 days without a BM. I was super worried that it was inflammation causing a "back up" and I was getting worse and not better.......but that turned out to be wrong.

I am now back on 1-2 movements a morning ---formed and clear of anything weird. And my latest scope report was clear of active UC.

superhenderson13 said...


i will typically go 3-4 times before 11am and then once when I get home at around 5pm and maybe once before I go to bed.

Anyone have a clue why I go 3-4 times in a span of 5-6 hours but then only go 1-2 times for the other 18-19 hours?

No idea why, but that was my experience exactly for over a year.

BTW, I failed Humira as well, but Entyvio helped. Good luck with it.