Does the tiredness with azathioprine lessen?

Hey everyone,

I have been on Azathioprine now for about 5 weeks and I am so tired especially soon after taking the tablet -definitely taking it at night. How long does this tiredness last? Hoping it is not permanent zzzzzzzz

For me, the fatigue is worst the first 2-3 months and then it seems like my body adapted to it. I just started it again after being off of it for almost 2 years...can totally relate to what you're exoeriencing! Hang in there!!

My GI initially told me to take it in the morning. I felt sick all day and discussed with a Dermatologist, I work in healthcare so have access for cheeky questions. The Dermatologist suggested taking it before bed and sleeping through the nausea. were you started on a high dose? I recall being started on low dose and gradually increasing although I'm TPMT heterozygote which could have been another reason.

Thanks for your experiences- 2 to 3 months isn't too bad. The sooner the better as it is like taking a sleeping pill without the foggy feeling the next morning.

Garthy- I am permanently on 50mg which is half a dose for my weight because I am classed as a "carrier" to do with TPMT levels. I am told if I had the normal dose it would be dangerous as my body holds on to drugs for longer than normal because of the TPMT issue. Always one to make sure your hospital has checked.

irish4me- I hope you are feeling a lot better again.