Fecal Transplant

Very few have had success for UC, but some do report success. Many have had success for treating c-diff, and this is becoming an option available in medical settings.

In clinical trials that controlled for clear UC diagnosis, prior failure of front-line medications, and included placebo treatment, there was no support for short term (6-8 wk) results. In longer open-label segments where people on placebo can switch over for an additional 6 to 48 week followup, there was some weak evidence of reduced symptoms, and some additional remissions were seen. This was not significantly significant.

As I see it there are important questions:

1) do some people who get good results have C-diff - even thought they do not test positive?

2) do some who get results have some other undetected infection (in addition to UC) that it treats

3) do some with UC (not an infection) see something like a placebo result (i.e., better, but not because of the poop)

4) do some have a preponderance of "bad" gut microbes that get adjusted or re-balanced. This would be a true UC treatment.

And a final question is why so many people with UC (not-c.diff) have no or little benefit.

Before I went for surgery, I would try this. For most with UC it has to be a DIY approach. FInd a donor with no disease, don't use a kid with immature gut microbes, minimize exposure to air, and do it weekly for a few months.

good luck

Connor,

I read how it has been used during a colonoscopy where the poop comes from a lab and is made up of a good diversity of individuals which helps strengthen what is being used to treat you.

If the FDA isnt allowing that anymore, does that mean that this treatment option isnt available for UCers and DIY is the only available option?

UCer23 said...
Connor,

I read how it has been used during a colonoscopy where the poop comes from a lab and is made up of a good diversity of individuals which helps strengthen what is being used to treat you.

If the FDA isnt allowing that anymore, does that mean that this treatment option isnt available for UCers and DIY is the only available option?

Yes, right now DIY is the only option if you don't have c. diff. It cures this remarkably fast, in days. If I had c. diff I'd forget the vanco and just go with FMT.

I have heard mixed results from the doctored version. One woman in the discussion group I'm on said that she got some kind of gut infection through a bad stool sample her doctor obtained. I personally don't feel that the odds are much better if a doctor does it. It's really just a glorified enema of donor stool mixed with saline. A lot of doctors only rely on the standard O&P test, and the basic PCR test for c. diff. These are very limited.

I think regardless of what option you go with, you should get rigorous testing of the donor. I've read many methods. The most popular seems to be choosing a donor with no history of GI issues, antibiotics, or chronic illness, and someone from your general race, weight and gender class. Then you get the stool tested with a comprehensive lab like Genova or DoctorsData. You also ask them to get blood work for hep C, HIV, and those kinds of things.

I'm skeptical that multiple donors is a good thing. It's hard to account for all the variables the more people that are involved.

I started FMT in early November and have been symptom free for over 2 months. about a month ago I also weened off my medications (salofalk tablets and enemas) and still have seen no relapse of symptoms after 9 years of being drug dependant with this disease.
I began by doing FMT everyday for a month and slowly tapered to less often. Right now I'm going them once a week, next week be every 2 weeks, etc. I plan on doing them once a month for at least a year.

There are many resources and studies online. I followed the protocol in the book "A Gut Reaction" by Sky Curtis, and Michael Hurst's ebook on his website fecaltransplant .org. They both did many treatments over a long period of time and have been symptom free for years. I'm hoping for the same results.

/www.webmd.com/ibd-crohns-disease/ulcerative-colitis/news/20160322/fecal-transplants-ulcerative-colitis#1

"We used this multi-donor concept for logistical reasons because of the number of infusions required for this trial," Paramsothy says. The research team also wanted to prevent patients from receiving an infusion transplant from a single bad donor. All patients in the study had active mild-to-moderate ulcerative colitis and phased out the use of steroid treatment during the study period.

Of the 41 patients receiving fecal transplants, 44% were considered to be in remission without steroids. That means they had no rectal bleeding or diarrhea. Only 20% of the placebo group achieved remission.

I am new here and am so thankful for such a wonderful site full of wonderful people! I was diagnosed May of 2017 with UC. I am going to be extremely honest and say that I have been pretty miserable since then. But glad I found this site to help cope

I had a fecal transplant November 1st after having c diff for 4 or 5 months, numerous rounds of failed antibiotics and 3 days in the ICU. It worked and it was such a relief. According to my doctors (and the way I feel) it didnt do anything to my UC. I am still flared and now working on trying to get that to go away.