Excessive Bowel Movements during the night

All,

My daughter was diagnosed with US in August 2017. Soon after that she was hospitalized with c-diff. She is still in a flare up state. She's had a fecal transplant and since then no reoccurrences of c-diff.

She is in college and in January went back to school. she was having severe stomach pains and had blood work done but the doctor seeing her said she needed to go to the hospital because of her lower abdomen being so swollen. She has been in the hospital since 2/9. no c-diff or other viruses, but she is having excessive bowel movements starting in the evening and into the night. last night for this period - 14. she was put on a low carb diet, still the number of BMs remains high. Doctors not sure why this is happening.

has anyone had this issues? If so, what meds or diet changes did you have?

thank you in advance for taking the time to respond. I truly appreciate this. I feel so helpless because I don't know what we can do for her.

hello, thank you for your quick response...
she just started humira in January 2018 so she has had the starting injections of 4 and 2. After that she takes injects of 40 mg every two weeks. she has taken two of those injections as of last friday. while in the hospital she gets IV predizone - 40 mg and azathioprine 50mg.
Stopped taking lialda per dr recommendation. with the other meds, no need for lialda. also noticed the lialda came out in a BM whole, not getting absorbed into her system.

colonoscopy showed severe UC
tested for c-diff to ensure she didn't have it again - negative
had CRP bloc test and FCP stool tests - nothing showing up that wasn't already known.
had "flexible" colonoscopy (can remember medical name - mini test) to test for cmv - negative

seems like it is some how related to nutrient absorbtion but not sure.

hope this helps fill in the blanks....much appreciate your insight

Is she currently taking any prednisone? I had a flare once that was worse at night and it helped to do a split dose of prednisone. It sounds like she is just waiting for humira to start working. The azaothorpine will take about 3 months to really see a difference as well. So sorry she’s experiencing this at college. Sounds like she has a good GI with a good plan. It’s oretty much the same plan I had except I started remicade instead of humira. Unfortunately what your are describing is a normal flare. At this point it’s a waiting game to see how she responds to meds.

Not eating after 2pm helped limit the number of movements at night for me. Not ideal, but at least you sleep a little better. That sounds like a lot of prednisone. That stuff is great short term but can really mess you up longer term. I had side effects on doses of more than 20mg. Be careful.