natural tnf inhibitors

i was just browsing on the web as i normally do and found this list of tnf inhibitors. i know a lot of us have tried tnf inhibitor drugs and have problems with them. i'm sure you guys have heard of most of this list, but i figured i'd post it for people who are new.

1. Fish Oil. It's no secret that omega-3's are one of your most potent inflammation fighters and studies have shown this to be true in the case of tnf as well. In one study of healthy volunteers, tnf-alpha synthesis was dramatically reduced by 74% as fish oil dosage was increased to about 9 grams per day. [1] NOTE: This is a hefty dose and higher than what is normally recommended for typical fish oil supplementation. Going with a smaller dosage should result in significant reductions according to this study.

2. CoQ10. A number of studies have shown that this antioxidant molecule reduces tnf levels.

3. Mediterranean Diet. One study the degree of adherence to a Mediterranean Diet was inversely related to TNF-alpha levels. [3] In other words, the more the Mediterranean Diet, the less the tnf.

4. Turmeric / Curcumin. Many studies have shown that this spice, present in yellow mustard and curry, inhibits TNF production. [4]

5. Green Tea / EGCG. EGCG is one of the most potent of all plant phytochemicals and has a host of miraculous properties. Multiple studies show that EGCG limits TNF-alpha production. [5]

6. Vitamin E / Alpha Tocopherol. This vitamin not only limits TNF release in arteries but also prevents oxidation of LDL and many other processes that lead to arteriosclerosis. [6] Although scientists have studies alpha tocopherol, it is probably prudent to only take mixed tocopherol Vitamin E because the alpha form can lower levels of the others (gamma, etc.).

7. Ashwagandha. This traditional ayurvedic herb has been shown to reduce TNF-alpha output.

8. Magnesium. There is strong evidence that low magnesium levels can negatively affect TNF levels. [8] Of course, one can easily get enough magnesium from a well-rounded, plant-based diet, but still many in modern societies do not.

10. Tart Cherry Juice. This cherry juice is, well, tart, but is well worth the effort as it tightly clamps down on rising TNF alpha levels. It is so powerful at controlling inflammation that is can reduce post-exercise muscle soreness and is used by many athletes already. 

11. Progressive Muscle Relaxation (PMR). One of the most powerful ways to control TNF alpha levels is actually not a food, juice or supplement but rather a time-proven relaxation technique. PMR was developed originally as psychological tool but has since proven itself to help with many health-related issues.

NOTE: TNF alpha is not the only cytokine that needs to be controlled.  In addition, many foods and a number of supplements favorably alter the upstream TNF inflammatory signaling.. Alpha lipoic acid and an extract of Korean Ginseng are examples of this. [10][11] [12] It should be noted, though, that other extract of Ginseng have actually stimulated TNF-alpha itself. [13] Quercetin, the miracle phytochemical in apples and onions, is also in this category.

CAUTION: The only potentially negative affect of cocoa that I know is that it does seem to stimulate TNF-alpha. [9] The same thing has been found in certain Korean Ginseng extracts as well. [12]

here's the website:

http://www.peaktestosterone.com/TNF_Inhibitors.aspx

ps- me and somedude will try the entire list at once and post our results.

Very helpful and interesting. Thanks for posting.

I'm a long time user of magnesium and vit E. The more magnesium that I take, the worse the diarrhea is?

Be advised that taking a few natural food sources of TNF inhibitors here and there, will not have the same affect as Humira which is a far more potent inhibitor. Nature puts it in these foods in smaller doses. Does Humira work right away, then the food sources won't either? I find it interesting though, to combine a few of these foods, supplements, and take them for a couple months and see if there are any improvements?

Thanks so much for posting this. I was just considering going on vitamin e because I saw it on many signatures here. This put me over the top.

If ALA "favorably alter the upstream TNF inflammatory signaling"

Why is it not listed as item #12 ?

i just bought some green tea extract today. i want to start taking it but am not sure of the dosage. most of what i find online is about taking green tea for weight loss. does anyone take this or have an idea of how much is ok?

i found this website:
http://www.umm.edu/altmed/articles/green-tea-000255.htm

it says to take 100-750 mg a day but on some bodybuilding websites it's 1000-1500 mg a day.

I always take ECGC because it is also a blood thinner clot preventer.

Anyone care to take a shot at my question above regarding ALA ?

thanks sean. i have the liquid extract and used a dropper. one serving is 2,000 mg and i took 500 mg to start out. also took it around 3 pm so i shouldn't have any more of a problem sleeping.

aguywithuc, i found this good info for ALA and also this link

http://www.foodproductdesign.com/articles/2009/06/alpha-linolenic-acid-an-underappreciated-omega-3.aspx

Alpha Lipoic Acid: The Natural Anti-Inflammatory

Unlike Vitamin C, which is water soluble and Vitamin E, which is fat soluble,
Alpha Lipoic Acid is a unique antioxidant that is both water and fat soluble,
which allows it to enter all parts of the cell to neutralize free radicals.
Alpha Lipoic Acid contributes to and is important for the production of energy
inside the cell by utilizing sugar to produce energy contributing to mental and
physical stamina, reducing muscle fatigue and neutralizes free radicals. Alpha
Lipoic Acid recycles and enhances the effects of both Vitamin C and Vitamin E.

Scientists first discovered the importance of alpha lipoic acid in the 1950s,
and recognized it as an antioxidant in 1988. It has been the subject of research
around the world, some being done at UC Berkeley by Dr. Lester Packer, a leading
expert in the area of antioxidants and a professor of molecular and cell biology
at the University of California at Berkeley. He believes that Alpha Lipoic Acid
could have far-reaching consequences in the search for prevention and therapy of
chronic degenerative diseases such as diabetes and cardiovascular disease.
Because it's the only antioxidant that can easily get into the brain, it could
be useful in preventing oxidative stress and damage from a stroke. [21].

Alpha Lipoic Acid is easily absorbed when taken orally and once inside cells is
quickly converted to its most potent form, dihydrolipoic acid. Because both
Alpha Lipoic Acid and dihydrolipoic acid are antioxidants, their combined
actions give them greater antioxidant potency than any natural antioxidant now
known. This also makes it important for regulating aspects of the immune system,
in particular, T-lymphocytes. [22].

The incidence of inflammatory diseases such as arthritis increases with age.
Free radicals promote inflammatory reactions, which antioxidants have been
successful at diminishing.

Scientists recently stimulated the inflammatory response of white blood cells,
resulting in an increase of Intracellular Adhesion Molecule 1 (ICAM-1), which
encourages white blood cells to stick to other cells, thereby inflaming tissues.
Alpha-lipoic acid, a potent antioxidant, was then added to the mix. Researchers
said the acid reduced the activity of ICAM-1 to levels in normal, un-stimulated
cells in a dose-dependent manner. It also lowered the activity of NFkB.
According to the study, these changes suggest that alpha-lipoic acid may help
reduce the effects of inflammatory diseases such a rheumatoid arthritis and
psoriasis. [23].

Suggested dosage for Alpha Lipoic Acid is 100-200 mg in divided doses daily.

SIDE EFFECTS: with alpha lipoic acid are rare but can include:

• Skin rash and the potential of hypoglycemia in diabetic patients.
• People who may be deficient in vitamin B1 (such as alcoholics) should take
vitamin B1 along with alpha lipoic acid supplements.
• Chronic administration of alpha lipoic acid in animals has interfered with the
actions of the vitamin, biotin. Whether this has significance for humans remains
unknown.11A.

Sibby, my husband's from Rome and trust me they eat tasty food their but it's in no way healthy from an IBD diet perspective (or what we think of one). And his family eat well with lots of fruit and veg etc. Also, the diet in the North or even the center is very different from that of a place like Sardinia. And the Greek diet is very different from the Italian. Spanish as well. So, nope I don't believe there is a "Mediterranean diet" - it's just one of those empty slogans people use. And AI disease is pretty high in Italy as well. Probably not as high as here but still - within our immediate circle of friends and family there we have severe asthma, three UC, one CD (only one of those is related), lupus, arthritis etc.

Stop eating anything with carrageenan, soy, soy lecithin, or and artificial sugar.

I'm getting there with a nopal supplement. Been taking it at exremely low dosages. So far notta much of anything. Been taking one, now two capsules per day. Max dose is six. I'll have to ramp it up soon and if still nothing, off to the trash heap it goes.

There are a lot more TNF inhibitors as I have found. Licorice, CBD, and Boswellia are very good and strong ones, all known to help with Colitis too.
I am wondering if you have tested the ones you mentioned?

Huh, this sure is an oldie post!

I know I have mentioned this before on here, but there is an elusive article that states apple peels are excellent natural TNF-a inhibitors. It actually came right out and said that ~8 apple peels (I think it was) per day gave the same TNF-a inhibition as a dose of Remicade.

I was floored when I read it. More so because they actually used the name Remicade in the publication. Then it seemed to have magically disappeared a little while later. An apple industry publication quoted it and also linked to the study. It was speaking to the benefits of apples.

Anyway, not that anyone could ever eat that many every single day. I actually tired for a few days out of sheer curiosity to see if it's possible. It's really not, hahaha. Sure was a lot of peeling. Red delicious was the type they used in the study.