Possible new approach for UC improvement-Easy if it works

This is interesting. I eat spinach, strawberries, and apples almost daily and I eat beets frequently.

I stopped taking Lialda six months ago after 5 years of remission and pathology reports from my latest colonoscopy no longer indicating UC (now indicating microscopic colitis instead). Maybe there is a connection.

I'll mention that study I have never been able to find again - but it stated that 8 apple peels a day equalled the same TNFa reduction as a dose of remade. Maybe the apples peels were really affecting this NO pathway first... Freeze drying and grinding to powder might be a way to access these. Not off the shelf supplements, but good old fashioned home freeze dried stuff.

Alternatively I believe you could juice all of those foods mentioned in the first paper once or twice daily and it would probably taste quite good.

Who knows Mark,many possible effects. I have been trying to figure out iNOS for years as have
the research doc's,the above paper possibly provides the missing piece of info. I started taking
Fisetin last night, we will see. I have been down too many dead ends,but this has merit. Iam still
not sure what is going on with macrophages, but this statement seems to cover it.

We demonstrate that NO derived from enterocytes alleviates colitis by decreasing macrophage infiltration and tissue damage, whereas immune cell-derived NO is associated with macrophage activation, resulting in increased severity of inflammation. We find that induction of endogenous NO production by enterocytes with supplements that upregulate ASL expression and complement its substrates results in improved epithelial integrity and alleviation of colitis and of inflammation-associated colon cancer.

OM

Arron: 500mg citrulline, and starting out with 50mg fisetin. I like to start slow on something
new. Will go to 100mg in a day or two. If I see any type of adverse events, I stop.
I have learned my lesson in the past.
Oldmike

Well I took some methyl folate the other day, and it gave me lots of D yesterday.
I took nothing yesterday, so have to start over, perhaps tomorrow.

Otherwise did not see much going on one way or the other.
Oldmike

For now have decided to not take fiestin, or just about anything else, like quercetin,resveratrol,
vitamin K2 MK-7. Seems they are all MAO inhibitors, monoamine oxidase which destroys serotonin.

I have indications that my serotonin is way high.
Serotonin mostly made in the gut, and it controls motility.

You really have to watch supplements, you take them to correct one problem but create others.
Oldmike

here is a bit of what is going on, might try and inhibit THP-1,tryptophan hydroxylase-1
/www.ncbi.nlm.nih.gov/pmc/articles/PMC3977648/

Post Edited (Old Mike) : 6/6/2018 6:18:36 AM (GMT-6)

D, Serotonin controls motility. All the stuff I was taking inhibits destruction of serotonin.
Fisetin is probably a weak inhibitor of MAO, so perhaps not a real problem. Tuff to find good data, but
the others are stronger.
But fisetin also inhibits arginase, it is so complex i really dont know what is going on.
I guess i will restart fisetin and see what happens.
Arginase inhibition could also be dangerous since it is in the liver for nitrogen waste detox,
converts ammonia to urea.
So quite complex.
Oldmike

Post Edited (Old Mike) : 6/9/2018 10:44:21 AM (GMT-6)

Here is one you probably never heard of.
you can get the oil or herb as a supplement.
This IDO/TDO tryptophan catabolism path is quite interesting
it might even lead somewhere. Ibuprofen will also inhibit IDO,via COX2 down regulation.
Years ago we had big threads on serotonin.
Another interesting aspect is that IDO dampens immune function at least
against cancer, one way cancer avoids immune attack. Perhaps the key
to cancer is to unleash the immune system.
oldmike

/www.ncbi.nlm.nih.gov/pubmed/28456683

then again of course there looks to be IDO inhibition risk
/www.ncbi.nlm.nih.gov/pubmed/22157149

perhaps IDO is good for UC, just goes to show messing with the immune system
one way or the other might be good or not.
/www.ncbi.nlm.nih.gov/pubmed/18547472

selfhacked a good summary page
/www.selfhacked.com/blog/causes-ibs-general-gut-dysfunction/#7_Excess_IDO_LowTryptophan

another inhibitor is green tea
/www.spandidos-publications.com/10.3892/ol.2012.761

this whole thing gets stranger and stranger, fish oil seems not so good cox2 involved
/www.nutritionjrnl.com/article/S0899-9007(05)00282-0/abstract

Post Edited (Old Mike) : 6/10/2018 10:15:46 AM (GMT-6)