Entyvio (Vedolizumab) Fatigue

I started Entyvio 4 weeks ago for UC. I've had pretty pretty significant fatigue from about a week after the first infusion on. I'm 2 weeks out from my 3rd infusion. I've been searching online to see if it's common. It's listed as a possible side effect but most of what I've found is people saying they have a day or 2 of fatigue after an infusion. Mine has been pretty steady for about 3 weeks now. Just wondering if this is going to go away or is this something that will be something I have to live with? Not sure if I can on a long term basis. A precursor to a server UC flare for me has been severe fatigue. This isn't quite on that level but it's pretty bad.
My history with UC, I just got it officially at 44 years old. I had it for a few years with some misdiagnosis prior. It seems to be somewhat seasonal. I got it really bad last year and ended up with almost a week in the hospital. I went on Remicade which worked but had some adverse effects (dizziness and numbness in my hands). At that point my doctor wanted to switch me to Entyvio but I decided (foolishly) to go without meds and see what happened. I was med and symptom free for about 9 month. The exact same time of year (to the week) as my prior flare it came back. We tried Usaris, Methasalimine and Lialda and they didnt work. The only thing that brought me out of it was Prednisone (had to go to 60mg). I've since tapered off as of a couple days ago. When the fatigue first appeared I thought maybe it was the UC coming back and brought my prednisone back up but I dont think that was the case. At this point just waiting for the Entyvio to fully kick in and keeping a close watch but it's tough feeling exhausted all the time. I go to the doc next week but just figured I see if anyone had extended fatigue from it.

Thanks

Remember too that tapering off of steroids can lead to a lot of fatigue. You've been tapering down from 60mg while you've been on the Entyvio, so it's possible that is the cause.

If it persists for several weeks after you've fully tapered off the pred, then it might be the Entyvio. But right now I'd say it's more likely the UC itself or the pred taper.

I never had fatigue from Pred before this current flare, but this time it has really been a struggle. I don't think it's the Entyvio because it's getting better the lower I go on the pred taper. Over the summer it was all I could do to drag myself home from work because I was so wiped out. I have been on Entyvio for over 2 years without fatigue issues.

I agree with the others. See how you feel after you have been completely off the pred for a few weeks. If you don't start getting more energy and you aren't still flaring then maybe it is the Entyvio,

Good luck!!

The reason I figured it’s the Entyvio is because it started about a week after my first infusion. It was like I hit a wall. I went from exercising every day to not feeling like doing anything. Up until that time I was feeling pretty ok tapering on the pred. I’ve had major fatigue from the UC so when the fatigue started I assumed it was the uc because I was down to 5mg of pred. I upped back to 20mg thinking that might stop it if it was the uc. I saw no change from being back up at 20 so I started tapering again. I’ve worked my way down again and have been off pred since Sunday. Bowel has been fine so right now it’s just the fatigue. I’ve had it way worse from the UC than it is now but it’s just been steady tired everyday. I feel weak. I’m an athlete and have exercised very steady through the sickness but lately I’ve been feeling terribly weak as well. I see my doc Tuesday so I guess I’ll see what he thinks. Hopefully it will pass. I really would prefer to be on entyvio over a biologic. Thanks for the feedback all.