Rash on ankles possibly from Entyvio ?

I have been on Entyvio since early March on monthly infusions.
It has been working great for me however in the past few days I am experiencing a rash on my ankles that tends to itch. Just wondered if anyone else has suffered this way.

It can be from the biologic or unrelated. Generally speaking, we have much higher incidence of skin issues, whether that is a dry itchy skin, contact-dermatitis, eczema, and psoriasis. More severe cases of UC are more prone to have extra-intestinal-manifestations of UC, whether that is skin issues, eye or sinus inflammation, joint pains, and other like things...ugh. We already know our immune system is crazy and it might not entirely be happy attacking just the large intestine.

Generally an allergy to a medication manifests itself as a body-wide rash, not localized to a small area like the ankles. Ankles makes me think that your laundry detergent against your skin has caused a reaction, due to strong perfumes, harsh chemicals, and the like (more a contact-dermatitis thing). For me, the rash was around my collar/neck, shoulders, and around the armpits; allergic reaction from my body wash and detergent.

I've had contact-dermatitis on a few occasions and it was related to the harsh laundry detergent, body soap and shampoo I was using, milder products helped immensely! Have you changed any of your soaps, shampoos, or detergents lately? Consider using psoriasis-safe soaps and shampoos (dove makes some) and you can ask your pharmacist to point you to the mildest products without perfumes that are safe for those with skin issues. You can try applying anti-histamine sprays, and applying anti-itch creams with hydro-cortisone to reduce the swelling and redness.

Certainly tell your gasteroenteroligist. Certainly see a dermatoligist.

limey, first of all lucky to have a nurse as your wife! I'm sure it's reassuring having her nearby through these ordeals. I'm in the middle of what seems to be a Humira triggered rash/psoriasis. I'm a month into it and desperate to see it go away. My last Humira shot was a week ago, so have a few weeks to bare through until it's completely out of my system. However as iPoop mentioned, mine is all over my body not localized. I've had to get on Prednisone for relief. Once I tapered down to 10mgs, it all started to come back. Now I'm at 20mgs a day and just holding steady. Good luck and hope yours goes away soon. Otherwise how has been your experience with Entyvio. That's next for me if and when the rash goes away.

I've been on Entyvio for about the same time frame, but I'm on the 1x every 4 weeks regimen (UC is aggressive and won't quit). I haven't had any skin issues related to the Entyvio itself (not that I believe?), but I have had skin lesions due to the UC flaring.