Liver Enzymes and UC

Hi Guys

Just had to get an abdominal ultrasound as liver enzymes have been up a bit latest values are a bit lower than a few months back at (AST 42 U/L, ALT 56 U/L). My GI also ran the following blood test below.

Alpha 2 Globulin: does anyone know if a value of 1.10 g/dL is considered high. Just got the result, from a serum protein electrophoresis test and I am flaring with the UC too at the moment. I understand it is a marker of inflammation.

Can anyone give me any pointers on this Alpha 2 Globulin.

Thanks, I take

1.2 gm of Mesalamine a day
Simponi Injection 1x per month

Doctor told me to lay off the Tylenol (I was taking maybe 2 a day at most) and I do not drink.

Thanks for getting back to me. I have been on Mesalamine (at this does) for two years. The Simponi about 6 months, as my GI Doc wanted to start me on a Biologic as Mesalamine was not helping me much by itself. I was diagnosed with UC ~2 years back.

Hello!

I’ve had similar elevations and underwent several tests, including a liver biopsy, to rule out autoimmune hepatitis, etc. My GI has seen patients with elevated LFTs while on TNF blockers (Remicade in my case, Simponi in yours). They also sometimes see elevations that correlate with disease activity. And some TNF blockers can cause autoimmune hepatitis.

I don’t drink and don’t take any Tylenol - I’m consistently elevated, especially when flaring. Now that I’ve switched from Remicade to Entyvio, the LFTs are somewhat lower but occasionally see spikes.

The thing is that both autoimmune hepatitis and (especially in men) primary sclerosing cholangitis can develop in UC patients more frequently than in healthy people, so if your LFTs stay elevated, it would make sense to ask for additional testing, just to be sure it’s not AIP or PSC. They can check for PSC with a special type of MRI.

Good luck!

That is good to hear! Hang in there