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Sky high Calprotectin!!!

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Ulcerative Colitis
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Posted 4/4/2019 12:35 PM (GMT 0)
Some results from sons recent hospital stay
Calprotectin over 5,000!!!
ESR 21
CRP 4.2
Sigmoidoscopy: nonuniform chronic active colitis, no granulomas, no dysplasia

Prior to hospital admission, he had been in a flare for over a month and is still flaring. The Calprotectin result is kind of freaking me out..Any thoughts?
Posted 4/4/2019 12:40 PM (GMT 0)
Nothing unusual about getting a Calprotectin in the thousands when flaring to the point of hospitalization. Read about many values that high or even higher over the years, reported here.

The "nonuniform chronic active colitis" is a form of IBD that's neither storybook UC or Crohns. It falls inbetween with the something like Indeterminate-Colitis or like Crohn's-Colitis depending on what was documented within the rest of that colonoscopy report and accompanying biopsy report. It's a gray area, where characteristics of both UC-like and Crohn's-like are seen. Nothign to worry about, we have posters here with Indeterminate and Crohn's-Colitis, and they're treated just like an UC is, and have a similar prognosis.
Posted 4/4/2019 12:46 PM (GMT 0)

iPoop said...
Nothing unusual about getting a Calprotectin in the thousands when flaring to the point of hospitalization. Read about many values that high or even higher over the years, reported here.

The "nonuniform chronic active colitis" is a form of IBD that's neither storybook UC or Crohns. It falls inbetween with the something like Indeterminate-Colitis or like Crohn's-Colitis depending on what was documented within the rest of that colonoscopy report and accompanying biopsy report. It's a gray area, where characteristics of both UC-like and Crohn's-like are seen.

I panicked when I saw the Calprotectin result. The biopsy results have me baffled, as I thought he had definitive UC.
Posted 4/4/2019 12:48 PM (GMT 0)
My Calprotectin has been sky-high too - >2000, over the reporting threshold, during a bad flare (and I wasn’t hospitalized at the time). So - it is scary to see the number but as my GI reminds me, how the patient feels and the degree of measurable inflammation on scope are more important.
Posted 4/4/2019 1:08 PM (GMT 0)
It really depends how prominent it was (superficial enough that the prep did it?, or did enemas do this?) or was it deep into the tissue and therefore an actual feature of this IBD? It could be nothing at all and still remain an UC, if deemed irrelevant. However, it does open the door to a change of diagnosis if confirmed in biopsies. Mostly, UC is expected to be uniform in appearance (UC is distal, starts at the rectum and is continuous-inflammation until it abruptly stops) where as Crohn's is patchy in appearance (common to have inflamed area, healed area, inflamed area, known as skip-lesions). So, if the inflammation was patchy and had rectal involvement, then that's Indeterminate. If it was very crohn's like, yet contained to the large intestine (a UC thing) then it's crohn's-colitis. Can't say without knowing the whole story, the one line from the report only says so much.
Posted 4/4/2019 6:48 PM (GMT 0)
5000 is high! I have had mine be 1600 and I thought that was high - but i've seen others with 2000+. Have they mentioned doing anything for rescue if the prednisone isn't getting him better fast enough? I saw in your other thread that he's starting to improve, that is fantastic and I am sure time will get him to where he needs to go. On the other hand, in the hospital they can offer more options, like cyclosporine, higher doses of IV steroids, or even a remicade infusion... some people respond nearly overnight to TNF blockers. With his symptoms being so virulent, it's not a bad idea to start thinking about options.
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