What would you do? In remission and choosing next med to quit

Short history, confirmed in remission in Feb of this year. Post-colonoscopy told to quit Lialda cold-turkey. Did, no prob.

I am now on remicade, 6MP, and rowasa. Doctor said I could quit either 6MP or rowasa next, my choice. Which would you drop next? He said cold turkey on either, no taper pharmaceutically necessary. Might make me feel better to do a taper of either, but no other benefit in it.

He said certainly rowasa is the weakest med and easiest to cease. He said there's obvious risks in taking 6MP indefinitely (low risks of skin cancer and lymphomas) and I've been on it since 2013.

Last remission I whittled away in this order: drop lialda, 6-months later dropped rowasa, 6-months later drop 6MP, and flared 6-months later. Thinking was stay on only remicade for maintenance. That failed.

Since you have already been there and done that I would proceed very slowly and with lots of caution. Maybe slow down the enemas, but don't stop them completely. Drop dosage of the 6 mp by 25 mg and stay there for a few months before dropping any further. How long has it been since you dropped the Lialda?

Being on only 1 med sounds great, but sliding into a flare by going too fast is risky ... especially since you've gone through that before. Even though you don't get side effects by going cold turkey on those meds, your body is used to them being in your system and just stopping them means your body has to adjust.

I would drop the Rowasa because if you need to restart the benefits are faster. If you drop the 6mp, it could take a while to gent benefit after restarting.

I’d say drop the 6MP cause remicade could still cover the immune system component. Rowasa is a topical application and who cares if you stay on that long term. I’d choose to give my body a break from the 6MP. But you have to go with your instinct.

It's easy enough to taper down on te rowasa. If you feel like you need it, you can go back up to doing it more often. Maybe you won't need it at all for a while, that would be convenient. I agree with CC though, whatever you decide, proceed slowly.

Why are you using the Rowasa?
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Why not stay on lialda and rowasa and wean off of 6mp which has the most risks. You can use rowasa a few times a week. I know you already stopped lialda but I think 6mp is the drug to slowly wean off.

I would drop the 6mp but i remember you saying you thought you flared as a result of dropping it the last time (although I'm sure there is no way to no for sure if that caused your flare 6 months later...seems a bit late to be the cause to me, but who knows with this disease).