question about entyvio side effects

I am on 6mp currently but reading that people go for entyvio next and avoid remicade/Humira as it works better if you never used anti-TNF.
I know Remicade/Humira has some side effects like Lupus or psoriasis. Does entyvio has those side effects? I don't read those side effects online but it is newer medicine compared to remicade and Humira, so like to hear from people who are actually using entivio of any side effect they had it.

The clinical studies showed no difference in side effects vs placebo.

My personal experience with this drug is similar in that I have experienced absolutely no side effects after more than 6 months on it.

This month will be my 3 year anniversary on entyvio. I’m very happily in remission — confirmed by colonoscopy with biopsy. I have zero side effects.

Entyvio kept my psoriasis in check, but gave me horribly debilitating joint and muscle pain. I would rather spend half my life on the toilet than go through that again.

greenuc said...
The clinical studies showed no difference in side effects vs placebo.

At all? Or just for the side effects the OP mentioned?

I'm 4 years on Entyvio. Started with infusions every 8 weeks, went up to every 4 weeks and now back to 8 weeks. For about 6 months I had a very mild rash on my forehead, which might have been due to Enytyvio, but it went away years ago. No other side effects.

The odds of entyvio helping to improve your UC symptoms are about 65%. Entyvio should be inherently safer than other 100% systematic biologics (like remicade, humira, and simponi) are, as Entyvio is a Site-Specific-Immunomodulator that targets just the gastero-intestinal tract. Safer as you're only suppressing the immune system within a specific region of your body, it is less likely that you'd get infections elsewhere within your body as would be the case with systematic Remicade.

What kind of side effects could you get and what are the odds? Everything carries a small degree of risk and it's good to understand what that's all about. Let's delve a little deeper into risk.

"about 4% of patients experience infusion-related reactions either at the time you are receiving your medication, or within 48 hours of it." Infusion reactions are headaches, raised body temperature, flushing of the face, fatigue and other things which are generally quite minor. Infusion-reactions are often prevented by taking tylenol and claritin/benadryl prior to the infusion itself.

"In clinical studies, approximately 25% of patients treated with Entyvio developed an upper respiratory tract infection at some point. These include bronchitis (inflammation of the airways), influenza (flu),
nasopharyngitis (inflammation of the nose and throat) and sinusitis (inflammation of the sinuses)." Entyvio is lowering your body's ability to fight off infections within the GI-tract, so you are going to be more prone to them as a consequence. It's the kind of thing that if you suspect you have an infection needing antibiotics then you should seek out treatment earlier, and sooner. GI-tract infections will develop faster and the symptoms will be worse while on Entyvio. As a general rule with all biologics they say you might, as an example, get an extra flu/cold a year than your normal. So, you're not super prone to them, by any means. Rather it is just an increased risk and something to be cognoscente of, and remain vigilant of while on it.

Entyvio does include a black box warning for PML, despite it never occurring to anyone taking that medication during the clinical trials or since it has been prescribed to patients. Entyvio was specifically designed to not cause PML, as predecessor medications within its class had done by using a different method of action.

Source: www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Risk-management-plan_summary/human/002782/WC500163289.pdf

Not sure why John keeps posting that Entyvio has a black box warning as I've corrected him in previous threads. It does NOT have a boxed warning.

I’ve seen that warning in my literature. Again no incidence of cases with entyvio but they put the warning there because it has happened with other biologics and entyvio is new enough that the studies aren’t as long term as others.