Frustrated!!!

It will take a couple of weeks at least. How long were you on Pred and what dose did you start at? You might want to switch to hydrocortisone enemas and alternate those with rowasa. Sometimes they work a bit faster than rowasa does.

For me usually about couple weeks, but I use it twice a day at the beginning of the flare.
Hope you will get better soon!

When I was first diagnosed in 2016 I was on 60mg per day of Prednisone. This time I had just finished being treated for a Cdiff infection so he wasn't sure if the infection was causing my troubles or if it was an actual flare up going on. After I weaned off the Prednisone I was still having issues so he put me on the Rowasa enemas. I've been on the Rowasa for a week now and haven't noticed a change yet. The constant feeling of having to go is brutal.

If you've been diagnosed with C. diff also, and it's reoccurring, it may be the source of your flair. It was for me. I had a 14 day course of Vanco, and my miserable symptoms, looking much like a UC flair, only subsided at the end of the second week.

Antibiotics both target, and can aggravate, C. diff, as you probably already know. They include:

Fidaxomicin
Metronidazole
Vancomycin

You need a GI or infectious disease physician, who is really experienced with C. diff.

When C. diff infections return, it's serious!. Doctors sometimes recommend a treatment to help repopulate the colon with healthy bacteria using a colonoscope. The procedure is called fecal microbiota transplant (FMT), it sounds worse than it is, and it has been very successful for many.

Good luck!

Thanks for the Cdiff info. My doc did a stool sample to make sure the Cdiff was gone before starting me on the Prednisone.
I am currently taking (4) 1.2gm of Lialda per day and I'm 1 week into the 4 week course if 60ml Mesalamine enemas.

I’m in a flare myself, going for 1.5 months now, on 40 mg of pred for 2 weeks now seeing results but the mesalamine enemas i feel are doing nothing for me as well - they used to do magic before, now as if they aggravate it more. I do not plan to decrease pred until bleeding has fully stopped.
I’m also increasing pomegranate fruit intake (spitting out the seeds) helps so much with bloating and digestion, try it! and Aloe Vera leaf fillet - i get the big thorny leaves from the farmer market and fillet them at home. Acquired taste
My biggest problem is the last part of colon, still have the urgency but getting better.
Question: i read here about suppositories, and I requested them from my Dr. and she prescribed Hydrocortisone ones. I though there were steroid ones.. hydrocortisone is for hemorrhoids no? Should i use these?

You could try hydrocortisone enemas. They work pretty fast for me.

I think I would ask to get another c diff test to make sure it's really gone (sometimes there are false negatives) and then try another course of pred, start at a higher dose and don't start tapering until you start to see improvement and then slowly taper. I hate pred, but it does work miracles.

Last time I was on it a couple years ago I was on 40 mg for 2 weeks with no improvement and thought I was going to end up in the hospital. Doc bumped me up to 60mg and I saw major improvement within 2 days and felt like I had my life back.

You probably should be thinking about another maintenance med since Lialda isn't enough anymore. Probably time to move to a biologic. They really aren't as scary as they sound. I was very resistant to biologics but am happy I did now.