CBD Oil Actually Working?!

All,
I have been healthy and without symptoms for 10 years. Something caused a flare-up (likely diet related) and I have had a week of strong symptoms and started UCERIS 5 days ago.

Wondering if anyone has seen ADVERSE INTERACTION BETWEEN UCERIS and CBD. CBD is known to slow the liver function required to breakdown steroids?

Any experience starting CBD when on UCERIS or Prednisone?

Thanks in advance.

dinkydonuts said: For this reason, you pretty much need to travel to a MJ legal state and visit a dispensary and try it out legally. For now, that is really the only way to know you're getting what you paid for. (p.s. appreciate your knowledable info)

I was in Denver last year and a dispensary was walking distance near our hotel so we visited it. Could not buy anything without a doctors RX. Don't know if I'd be able to get an RX since not a resident. Has anyone tried as a non-resident? I would really have liked to try quality CBD.

In my state I could get a card of I had Crohns, but not UC. Seriously thinking of trying at least CBD oil

I posted this today on a reddit sub but wanted to share it here to get other peoples input.

I recently started vaping CBD. 2 days later I started to bleed again and I continue to. I just had a flare last month but I have been doing great and no blood or anything. So to start bleeding again is alarming especially since I just started CBD.

I started to do some research and it turns out CBD at certain levels will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds. https://www.projectcbd.org/science/cannabis-pharmacology/cbd-drug-interactions-role-cytochrome-p450

I am on Lialda and Canasa which are both forms of Mesalamine. From what I am reading Mesalamine requires bioactivation by cytochrome P450 in vitro and in vivo. https://www.abcam.com/mesalamine-ab143052.html

If all of this is true, which it seems it is, I just caused another flare by taking CBD because it is inhibiting my body to process Mesalamine (Lialda and Canasa). ***

Post Edited (Rensi) : 7/9/2018 11:20:36 AM (GMT-6)

So I am still bleeding but it has significantly reduced, I am not vaping CBD anymore.

I am continuing to research it but everything I have read shows CBD at certain dosages does inhibit cytochrome P450 but there is so much unknown due to the lack of overall research especially in vivo on humans. However I think what is key here is the dosage of CBD and how receptive (metabolism) your body is to CBD. Was I taking to much? It's possible. Did I vape at the wrong times, that too is possible. I was vaping a few minutes in the morning after taking my medicine, a few times during lunch and then also vaping before bed a few minutes after taking my suppository. I was basically vaping at almost the same time I took my medicine and I had CBD in my system all day.

This is an interesting post about a year ago on the CBD sub about this very topic.
https://www.reddit.com/r/CBD/comments/6l4ibf/cbd_and_cyp450cytochrome_p450/

Here are two great reads but pretty complex, I'm still trying to read through them.

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/

Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576600/

"I would be interested to know if anyone has dropped any expensive meds like Entyvio and are using only the CBD oil." That sounds like a really bad idea to me.

Does the CBD oil get you high or anything like that?

I like to be able to use my brain and have energy and not just sleep all day.

https://www.youtube.com/watch?v=5ybu-_tDXb8

Post Edited (Poppysocks) : 12/17/2018 4:50:43 AM (GMT-7)

Even if you have third-party lab reports listing the batch number of a company's product, you have to trust the company that they don't just print that batch number on all their batches. I am not sure if any criminal penalties exist for a company lying like this for stuff that isn't regulated medicine.

So my strategy is, buy from the largest most well-established company you can find, because they have the most to lose if they do sloppy or underhanded stuff.

I've started this a few months ago and I'm doing much better now. Very well formed. However I chock at least half of that up to that I drastically cut back on alcohol when I started this stuff. Also I started taking turmeric.

I don't like jumping to conclusions - so this is still too early for me - for the past 2 weeks I have been taking CBD oil regularly - the strength I'm taking is 17mg per 1 ml - 2 full squeezes of the dropper under my tongue in the morning and 2 at night. I saw immediate results within 3 days, I stopped enemas - I am only taking oral mesalamine pills for maintenance.
For me, CBD oil ended this 7-month flare, the worst flare I have ever had since my 2013 diagnosis.
Earlier this February I also stopped infusions - they were not working for me - the enemas were keeping me going, but they never got rid of my urgency and the messed up bowels 3-4 times a day. I had little energy.
With CBD oil I now go once a day - sometimes 2. No urgency, and I've started to experiment with different foods outside of my diet. so far so good. Good solid formed stools... I got my energy back, I got my life back. I was stuck inside my house for the whole entire winter.
My only fear is that CBD oil benefits may wane off.
Again, this is still too soon - only 2 weeks in - I will keep you guys posted. but I suggest trying out CBD oil - get a good brand - and take the right dosage - and take it regularly, don't skip doses. Maybe you'll be as lucky as I got.

that sounds about right. I have not tried it during a major flare, but I cannot image it to do anything to a major flare. CBD helped me with my last part of the colon, the urgency, the cramps when going #2, I was going between hydrocortisone enemas and mesalamine enemas for more than a month and could not get it right. When I started CBD I found the enemas no longer neccessary.
I did something drastic as well 1.5 months ago - I stopped Entyvio infusions.
I never felt Entyvio did anything for me, actually, I felt it did not allow me to get better. aside from this 6 month flare I just went through, I typically have had a mild case of colitis. So Entyvio was an overkill to begin with.