No D for the past 2 months How I did it

Stopping or cutting way back due to adverse event today. Stools too hard to get out.
Why it has taken two months to do this don't know. 11/3/2021


Ok have taken Calcium,Mag,and Zinc by themselves many times for UC - no to little effect.
Large amounts.
Now taking only one pill of this at night. Which is 1/3 dose. See below.
Cost 3 or 4 cents a pill depending where you buy it. Can get on Amazon or just about anywhere.
Take K1 once is a while, just added vitamin C to see if can improve more.
By the way have been researching for 41 years. Those of you who dont know me got UC-1980.
Yes, I smoke. Full discosure. Still some blood. No MED's since about 1982.
Anyway my current theory is upregulating Intestinal Alkaline Phosphatase/IAP, which detoxifies
LPS,from bacteria. LPS gets the gut immune system really upset.
IAP needs Cal/Mag/Zinc to work correctly. Also some Vitamin K.
Also inorganic phosphate deactivates IAP s make sure supplements have none, or what you
eat such as store bought bread.
This thread has a lot of info
https://www.healingwell.com/community/default.aspx?f=38&m=4260455


https://www.iherb.com/pr/nature-s-bounty-calcium-magnesium-zinc-with-vitamin-d3-100-coated-caplets/32229?gclid=cj0kcqjwlomlbhcharisagijg7kbxq9rgfz_bexvglw6u5hrtw5ezufc6rr8rhwbjgeyazcqsvw5ln4aagzaealw_wcb[url]

Will this work for anyone else. Don't know.
Colon has to get used to solid stools. This is insane, would not post this if not working.
Waited 2 months before posting, so I could be pretty sure it was doing something.
Oldmike

Post Edited (Old Mike) : 11/3/2021 10:01:00 AM (GMT-6)

Within a few days.
Would normally have soft stool which would progress to D,might go 10 or more in one day.
Now real real solid, and no progression to D. Please note taking one pill, which is a 1/3 of dose not even close
to RDA. IAP needs all 3 minerals to work properly,plus enough vitamin K to work properly.
Oldmiike

Post Edited (Old Mike) : 10/28/2021 11:57:36 AM (GMT-6)

Interesting! Glad to read that you're getting steady bm relief, Mike, and wish you continuing success with most recent regimen. / Old Hat (40+ yrs with left-sided UC; in remission taking Colazal)

Interesting Old Mike. It backs up the (unproven) theory that there is no such thing as autoimmunity but rather the issue is a lack of immuno-modulation at certain sites caused by bio-mechnical issues, infection or whatever. And the key to figuring out each's problem is whatever up or down regulates the fault in the immune system at that weakness point.

Autoimmunity, as we call it, is a signaling issue.

That’s fantastic OM!

Hey Old Mike,
Long time reader here. Never post though.
I respect your opinion. You've probably clocked in more research hours into UC than anyone on the planet.
The fact that you've had UC for 40+ years gives me hope. (I'm entering my 6th year).
You should write a book..Get famous...Get rich....

Anyhow,
Do you purposely only take 1/3 of a dose?
Also do you take Vitamin K regularly?
Take anything else to strengthen Mucus barrier?

Thanks.

Hi Mike...great to see hou are now enjoying perfect poops!
Curious, however, if you've had any blood testing over the many years to have those minerals, etc blood tested?

q

But in general...have you been tested for those specific minerals...just that it would have been of interest to know before starting the supplements. Keep us updated how you're doing.

q

Agreed. There is little correlation between a person's magnesium blood test reading and whether or not they are deficient. These minerals are stored elsewhere in the body and are removed when needed into the blood. The blood readings for most will always be within range even though the stored minerals in the body are quite low,

OM, does you UC present with any extra intestinal symptoms e.g. joints, eyes, skin. If so has you new regieme had any positive affects on these?

Very interesting OM. What you are describing is the classical IBD arthralgia where the poorly modulated immune system over-reacts to normal bio mechanical stress but without producing arthritic manifestations.

Please do report to us if you feel your new approach is also having a benefit for these EIMs.

D

Yes its about having too many cytokines like TNF and IL6 etc. The mouse models have always shown that. I know you said you are not currently on meds. Did you try anything beyond pred....immunosuppressants or biologics?

Have you ever tried high dozes of supplements that are anti-TNF? Like tumeric, slippery elm and fish oil?

Your mix of Mg, Ca and Zn may be regulating the immune system in the precise way that it needs to be done for you.

Also another way to induce an overreaction of TNF is excessive exercise. I wonder do marathon runners and triathletes experience IBD at a greater rate?

Post Edited (damo123) : 11/1/2021 10:46:46 AM (GMT-6)

Many IBDers suffer zinc and magnesium deficiency because of absorption issues.

https://labs.selfdecode.com/blog/low-alkaline-phosphatase/
Low levels can suggest zinc, magnesium, or protein deficiency

No never tried LDN.
Oldmike