cytokine storm

From my 10 years experience with UC I have this feeling that if you are in the beginnings of a significant flare that, in order to being to get better and for meds to actually start working you to remission, that the flare must first "pass through", i.e. the cytokine storm must happen and that stalling in with pred and the like only lets things linger at a low grade level but that the flare and the storm is still there.

Anyone share this view, that the cytokine storm must in effect pass through your body before you can begin to heal?

I unfortunately must disagree with this view, but I understand where it comes from. In UC, the body has lost the ability to regulate its own inflammation, so it cascades until the patient is in severe condition. It's not a process like, say, the inflammation that happens in a cut, and eventually it goes away when the cut heals. In that case, suppressing inflammation is counter-productive.

But with UC, the bowel wall becomes compromised, gut bacteria start invading the bowel wall, and then inflammation spirals out of control until something intervenes to stop it. In severe cases, the person will die if the natural process is allowed to continue.

In my first flare I was very reluctant to take prednisone because I googled the side effects. My inflammation just spiraled and spiraled until I was nothing but skin and bones, and in the hospital for 6 weeks. Letting it do its thing leads to death. Those emergencies are how many UC patients get their initial diagnosis.

This might get you started with research on this subject. While searching you will run into a lot
of covid articles,of which you dont want for this.
Odmike
https://www.sciencedaily.com/releases/2016/02/160216181711.htm