Hambo88 said...
Logically i think we dont have genetic problem regarding the ROS. Because the ROS cause only problem in our bowel.
we dont have any inflamination in other part of our body.
So i think logically we have to fix "the system" only in our bowel because the inflamination is here.
Question is what is the problem in our bowel.. but I think the microbiom map making should be the first.
Because if our microbiom is "off centred" this can be a non comformity maybe.
My GI told me that he saw such cases when the patient received a medicine which did not work and after the FTM the same medicine has worked.
ROS cause problems everywhere, not just the colon. Disclaimer though, ROS are used as healthy signalling molecules in the body. We need ROS to live, just like we need antioxidants to live. It's all about
balance. When ROS are out of control, they damage body tissues. For example, mutations in SOD means that radical oxygen like superoxide doesn't get broken down into hydrogen peroxide (H2O2) as readily. Hydrogen peroxide is actually not as harmful as some of the other ROS we see, but it's still harmful. In people with SOD mutations, cardiovascular problems can strike earlier, like heart disease. Heart disease is usually inflammatory in nature.
Dysfunction in hydrogen peroxide reduction manifests in the colon in UCers because the colon has the most ROS in the body. It's where all the metabolic wastes of the body are sent for excretion for the very fact that they are toxic and damaging to cells. The colon copes with this with high cell turnover in the colon wall. And within the colon, the area with the highest toxicity and lowest reduction capacity (in anyone, not just UCers), is the last 12 inches of the descending colon. This is why UC starts in the rectum and moves up from there. If someone has poor reduction capacity of H2O2, then over a lifetime that will manifest in the colon. It will also manifest as various other metabolic disorders because the H2O2 doesn't just flow outward from cells towards the colon, it flows inward to all of the cellular compartments, including mitochondria. It's why people with so-called "autoimmune" also have low energy, poor assimilation of nutrients, and other comorbid conditions ("multiple autoimmune"). In reality the immune system functions fine, but the metabolic pathways of the body are being disrupted by excess hydrogen peroxide, which oxidizes key points in pathways. UC is therefore a cellular metabolic disorder, NOT an "autoimmune" disorder. True autoimmune is usually very rare and genetic. Some component of the immune system is missing and causes it to behave in a damaging way. UCers have normal immune systems, they just have poor redox capacity in their cells.
The microbiome plays a role in so far as the level of oxidative damage being done to the bowel, and the quality of bacteria that invade the colon wall when H2O2 causes the wall to break down. For instance, if the microbiome is full of short chain fatty acid producers, then they will be producing butryate which feeds coloncytes, which poses less of an irritation. Butryate can also reduce hydrogen peroxide, topically... it doesn't enter the cells though where H2O2 is being made. If the person has a poor diet and very high populations of LPS producing bacteria, then those gram-negative species will cause major immune responses when they invade the gut wall. This is why UC improves with certain diets, but never goes away. You're just improving an aggravating factor, but not the root cause.
The problem is that inflammation and bleeding themselves cause dysbiosis. Inflamed colon tissue cannot be properly colonized by the full diversity of healthy colon flora; only certain species reside on inflamed colon, mainly the injurious kind. LPS bacteria have a field day when blood is in the colon. It makes them reproduce like crazy, which displaces all the good bacteria. Healing the colon wall will stop the bleeding which will stop the dysbiosis. You can't heal UC permanently by just tackling dysbiosis. You can cause temporary remission at best, but the colon wall is still compromised and as soon as a high ROS producing event takes place in a person's life (stress, gut infection, etc), the colon wall will suffer fast erosion from H2O2 and UC will come right back.
People who don't have UC can eat like garbage and also have high LPS species. It's not good for them, but it doesn't cause UC. The reason is that normal people don't have H2O2 disrupting their colon wall IN ADDITION to the messed up gut flora from bad lifestyle.
This is why most GI doctors say that diet is not related to UC etiology. They are technically right, though some (in my experience) outright say that diet has NOTHING to do with UC. Those ones are wrong because at least if you are nourishing healthy gut flora, it will make the colon injury less severe. I have had lasting relief from eating a diet that fed SCFA producers in the colon while minimizing LPS species. My UC went from a 10 to a 2 with that method. However, it didn't make my UC go away completely. That's because H2O2 is still causing damage.
The key to really curing UC is therefore a novel antioxidant that neutralizes H2O2 in the entire body. After a period of time of taking that antioxidant, the gut wall would heal and the vicious cycle of gut wall corrosion followed by bacteria infection and inflammation would be stopped forever.
Post Edited (VanJordan) : 3/24/2022 2:04:49 PM (GMT-6)