Hydrogen peroxide and UC.Is it the cause.

if i think according to your logic " that the colon is the most stressfull place in our body and if we have ROS elimination problem here will be first sign of it"
So in this way my question is why have the people arthritis?
This is not in the colon. Ok more kind of thing can cause inflamination....
But in the gut as well.
very clear to me that we should increase our ROS elinmination functions of our body : to take glutathion, c vit etc. ( but earlier you said to take antioxidant this is not the best way to fight against the ROS in our case)

Oligodar that is why I added the study to this thread.
Perhaps the key is, concentrations do not exceed a certain physiological range.
Or perhaps we are not producing peroxide in the correct area.
A puzzle for sure. This is the first I have seen where peroxide is protecting the colon,but have not
done a lot of research in the last 3 or so years.
here is another
https://www.nature.com/articles/mi201774

oldmike

Post Edited (Old Mike) : 3/25/2022 10:58:48 AM (GMT-6)

Oligodar said...
I have not read the whole thread but this study (mice model) is quite contradictory:

. said...


This study together with our recent report on Lactobacillus overgrowth in Nox1–4 inactivated mice (CybaVil-cre) highlights the importance of bacterial-derived H2O2 at the intestinal barrier and reveals that intestinal homeostasis is maintained and even improved by H2O2 as long as concentrations do not exceed a certain physiological range.

https://www.sciencedirect.com/science/article/pii/s2213231717309163

ROS have physiological functions. They serve as cellular signals for all kinds of normal things. For example, when cells break down glucose via the glycolysis cycle and then the TCA cycle, oxygen radicals are produced as electrons pass through the electron transport chain (ETC). This is because oxygen is the end receptor in the cycle. If it gets too loaded with electrons before they can be properly channeled in chemical energy production, it makes superoxide. Superoxide breaks out of the ETC completely and floats off to wreak havoc, but is usually intercepted by SOD. Superoxide then gets broken down by various processes (like SOD and GPx) into water. However, as part of normal function, if ROS become elevated, they initiate a signalling cascade that makes the cell resistant to insulin. Insulin in turn stops importing glucose into the cell. This series of mechanisms likely allows the cell time to mop up some ROS before it continues oxidizing glucose. It also signals to other messengers that glucose metabolism is taking place. However, people with high oxidative stress in their bodies are more likely to develop type II diabetes, because the ROS signalling becomes too excessive, triggering insulin resistance, which keeps glucose in the blood plasma, which leads to disease.

H2O2 is a very important messenging molecule. It has healthy functions, *at the right concentrations*. In UC, the concentration is too high, and causes destruction to the colonic epithelium. There is nothing contradictory about what you read in that report. Normal levels of H2O2 maintain a healthy gut environment.

It's key to understand that ROS and antioxidants are both needed by the body. Popular marketing has made it seem like antioxidants = good and oxidants = bad, but it's not this black and white. Both are needed, in various quantities, in various functions, at various moments in the cell. Too much of either causes disease. For example, some cancers can be treated with antioxidant therapy. Other cancers are made WORSE with antioxidant therapy and ROS therapy kills those cancers.

It's a complicated subject!

Post Edited (VanJordan) : 3/25/2022 5:07:08 PM (GMT-6)

vg_guy said...
This is a fascinating and exciting topic. I too am excited for his paper to come out.

VanJordan said...

I have had lasting relief from eating a diet that fed SCFA producers in the colon while minimizing LPS species.

Just curious what this diet consisted of?

Also what are your thoughts on consuming NAC (N-acetyl cysteine) which would help increase glutathione production? Would this harm someone with genetically reduced regen capacity?

I don't think NAC helps UC, ultimately.

As for diet... colourful foods, especially those high in anthocyanins like blueberry, cherry, etc. Pomegranate in all forms is the highest potency. Red polyphenols are especially potent for feeding good gut bacteria. Red dragon fruit, strawberry, cranberry, red grapes, raspberries, etc. Red quinoa.

Certain FOS foods like garlic, globe artichoke, leek, onion... if you can tolerate the sulfur.

Legumes, if tolerated. Brown lentils are especially good.

Partially hydrogenated guar gum (PHGG) feeds the SCFA producers. So does psyllium seed powder (NOT husk). Zinc acetate scales back the hydrogen sulfide producers, which are usually high in UC.

One must cut out all artificial sweeteners, synthetic and processed products, all chemicals. These cause major dysbiosis. Whole foods only.

This is all based on tolerances, of course. And if you're sensitive, then start with small portions at a time. i.e. one teaspoon of brown lentils per day. A lot of people say things "don't work" because they eat huge portions to start with. Once gut bacteria start shifting for the better, you can increase quantities.

Seeker275 said...
How useful would clinoptilolite / zeolite as an antioxidant supplement be here?

It has no effect as an antioxidant, but it can mop up bacterial toxins like LPS which sometimes has a soothing effect. The problem is, it also mops up nutrition, like minerals.

I have used clays to no effect, but I have met some UC patients who get some relief. I don't personally think it's the answer.

Post Edited (VanJordan) : 4/29/2022 4:58:33 PM (GMT-6)