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Posted 7/18/2022 9:01 PM (GMT 0)
What is the most bioavailable choice for Curcumin?

I dunno for sure but this brand advertises 45 times better absorption:
https://www.lifeextension.com/vitamins-supplements/item02324/advanced-curcumin-elite-ginger-turmerones-turmeric-extract
Posted 7/19/2022 1:35 AM (GMT 0)
The most absorbable is phytosomal curcumin (a.k.a curcumin phytosome), with the trade name Meriva. Many brands have Meriva curcumin.
Posted 7/19/2022 4:10 PM (GMT 0)
which antioxidant can be also good againtsr the ROS? what are not in oxidized form?
Posted 7/20/2022 12:20 AM (GMT 0)
I don't have a huge list, but these are ones that I know help with UC:

Grapeseed extract (NOT to be confused with grapeFRUIT seed extract)
Curcumin
Sulforaphane
Vitamin E (broad spectrum is best)
Vitamin C (natural forms are best, as ascorbate/ascorbic acid is oxidized and not good for us)
Pure grapefruit juice (if you're not on conflicting medications)
Rutin
Quercertin
The dark purple/red anthocyanin flavonoids of blueberry, cherry, bilberry
R-DHLA (R-dihydrolipoic acid), the reduced form of R-ALA which does not appear to be available on the market
Food-derived retinol (the active form of vitamin A), like from bovine liver or codliver oil (vitamin A palmitate does not count)
Astaxanthin

These all show activity against hydrogen peroxide, to varying degrees. Some may not target the bowel specifically, but if you can reduce hydrogen peroxide anywhere in the body (like the liver), then there will be downstream benefits to UC due to increased reduction capacity in the body.

There are probably others.

Now that it appears highly likely that hydrogen peroxide is the root cause of UC, it's a simple matter of experimenting with a wide variety of reduced-form antioxidants to fix the problem. It's good news. The pharmaceutical industry could probably come up with a really potent, targeted antioxidant to cure UC, but even if that never happens, the world is full of antioxidants that we can try. I was able to go into remission just from using 3 or 4.
Posted 7/20/2022 11:02 AM (GMT 0)
I gotta say, Grapefruit Juice made me feel really worse. I might have an allergy (this would be my first foodallergy tho), but it made my inflammation in my joints way worse, my stool felt hot and my throat and tongue got sore. At first, I thought I got the flu, but I was able to pin point it on the grapefruit juice. Just started it again, and the symptoms showed up again. I'm passing on this one, even tho I liked the taste of the fresh juice.

I'm also trying some Chaga and Cistus Incanus Tea right now, which are really high in Antioxidants. I remember drinking a lot of Chaga Tea the last time, I entered remission 5 years ago.
Posted 7/20/2022 12:30 PM (GMT 0)
Hey Van Jordan,

Got this email back from GeroNova Innovations regarding R-DHLA capsules that looks promising.

(Q)-Do you carry R-DHLA capsules. If so, could you please provide a link for it.

(A)- Thanks for your interest in our products.
It's in the works but won't be available until late this year or early next.
When we have it ready, it will be available on our website.

Please check in again at the end of the year.

Best,
Sitara
GeroNova
Posted 7/20/2022 1:45 PM (GMT 0)
If Dr. Pravda says that hydrogen peroxide is the root cause of UC, then what does he say is the root cause of hydrogen peroxide, where does H2O2 come from?
Posted 7/20/2022 7:08 PM (GMT 0)
That is exactly what I was going to ask...

Why does somebody suddenly have a hydrogen peroxide issue at some point in their life? What causes that?

1Wish
Posted 7/20/2022 9:57 PM (GMT 0)
I wrote about this extensively in the other thread.

Everyone produces hydrogen peroxide and other oxygen radicals in their cells as a byproduct of aerobic (oxygen) metabolism in their mitochondria. Normally, at the end of the electron transport chain where food energy is converted into chemical energy (ATP), oxygen (O2) captures the spent electrons and is converted to water (H2O). The process isn't perfect though, and sometimes oxygen radicals are created (like superoxide, O2-). Superoxide is highly destructive to cell structures and DNA. The body deals with it by first converting it to H2O2 (peroxide), which is still corrosive, but not as bad as superoxide. In healthy people, enzymes like SOD (superoxide dis mutase) and GPx (glutathone peroxidase) then reduce hydrogen peroxide to water. In people with UC, there are genetic mutations in SOD and GPx function, so not enough enzyme gets produced or the enzyme that is produced is malfunctioning somehow. Enzymes are proteins with complex structures and genetic deviations can render their active sites inactive or underactive.

For myself, I have double recessive SOD2 mutations (-/-) and so do a lot of UC patients I've spoken to who have done their genetics. So their SOD capability is limited.

Because oxygen species pass readily through cell walls, when peroxide in the cells reaches high enough concentration, it diffuses through the cell wall and into other parts of the body. All organs are affected, which is why people with UC are prone to other kinds of inflammation dubbed "auto-immune." Without sufficient internal antioxidant measures available, people with UC have to rely on external antioxidants from food sources to deal with this.

Unfortunately, life is messy and something and simple as stress will release cortisol which instructs mitochondria to produce energy even faster, which amps up H2O2 production. If you have sources of oxidation in your life, like crappy food, pollution, low grade supplements, etc... then even less H2O2 gets resolved.

The colon is the most susceptible though because it has high cell turnover and oxidative activities there are the highest in the entire body, especially in the distal colon.

I suspect oxidation is the source of many "auto-immune" diseases and therefor redox medicine holds the key to their resolution.
Posted 7/20/2022 11:33 PM (GMT 0)
So in other words the root cause is genetics plus environment?
Posted 7/20/2022 11:52 PM (GMT 0)

poopydoop said...
So in other words the root cause is genetics plus environment?

There could be many different reasons for SOD or GPx malfunction. Heavy metals can inactivate them too, which is why people with heavy metal toxicity have so much inflammation.

But I would say yes, for the majority of UCers the root cause is genetic. A dysfunction in the native antioxidant systems of the body.

The tipping point is different for everyone though. For example, some people get UC because of crappy diet (like from oxidated fats and synthetic ingredients), and once they get UC they discover clean eating and their UC goes away. Then they proclaim that UC is just about diet. In reality, they had a severe deficit of dietary antioxidants that got corrected once UC showed them their diet was poor.

For others that have a more major oxidative problem, diet alone doesn't work. about 10% of UCers are in the severe/refractory category (I am one of those people), and it's likely because of really bad genetics plus oxidative burden. In other words, genetics are primary but they have the perfect storm happening. Looking back, I had very mild undiagnosed UC for 2 years, but then an important relationship ended and it became 10/10 severe and life threatening.

The body is adaptive and works hard with the tools it has, but if the toolset isn't good then adding more harmful variables just threatens the house of cards even more.
Posted 7/21/2022 12:05 AM (GMT 0)

VanJordan said...
In healthy people, enzymes like SOD (superoxide dis mutase) and GPx (glutathone peroxidase) then reduce hydrogen peroxide to water.

If this is true then supplementing with Superoxide Dis Mutase should be helpful.

https://www.lifeextension.com/vitamins-supplements/item02361/sod-booster
Chokeberry (A. melanocarpa) Extract
Chokeberries have one of nature’s highest polyphenol counts—greater even than blueberries.3 Specifically, chokeberries are packed with polyphenol compounds called anthocyanins.4 Why does this matter? Because chokeberry anthocyanins promote SOD production.
During a two-month study, participants were given 300 mg of the same chokeberry extract in SOD Booster every day. By study’s end, supplementation resulted in a 29% increase in superoxide di****ase. Interestingly, levels of glutathione—another powerful antioxidant—increased as well.
Extramel® melon pulp concentrate
Extramel® is a concentrate of a special variety of a French melon. This melon has a long shelf-life, theorized to be in part because of high SOD activity (and therefore cellular longevity) in the living fruit.
Posted 7/21/2022 11:26 AM (GMT 0)
Hi VanJordan, first of all thanks for all the answers and posts in here - much appreciated. I've been reading old mike and co in here for many years so thanks also to those guys.
I really like the sound of this theory and many of the ideas seem to fit with how I have reacted personally over the years- for example red meat, dairy and alcohol are the three main triggers for me to avoid. I am on mesalazine tablets and enemas. The tablets keep things fairly quite but every few weeks I have to use the enemas to stop new bleeding in a constant cycle. Incidentally the bouts of bleeding seem to coincide every time with if I get a cold - could that fit with the theory somehow? I have been on holiday in the past at all inclusive resorts where you can eat anything and took this as a challenge to fill myself with as much healthy fruit and veg as possible (unsustainable at home) - these have been the only times in recent years my bowel movements have been great. - Is this possibly a likely combo of increased butyrate and antioxidants?
So on that note I've gone and bought a ton of supplements as follows (I'm UK based).:

Pomegranate extract - supplemented.co.uk -
**Pomegranate Extract (90% Ellagic Acid) 250mg Capsules - 180 - £11.**

Milk Thistle - Amazon - Milk Thistle Extract 7500mg - 80% Silymarin - £6.99

Grapeseed extract - supplemented.co.uk (tablets)

vitamin C: camu powder - [Superfood Outlet Organic Camu Camu Powder 1kg](https://www.amazon.co.uk/gp/product/B07VTMJQKG/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A1VXL2W0ZMJK3 "Superfood Outlet Organic Camu Camu Powder 1kg") £24.99, rosehip powder, or acerola cherry powder

Orange Juice and cherries consuming more of.

Rutin - 50-100mg/day - Amazon -[Rutin 500mg | 120 Vegan Tablets | Natural…](https://www.amazon.co.uk/gp/product/B08TQPVBD9/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A4GQDSVHXXKAQ "Rutin 500mg | 120 Vegan Tablets | Natural Bioflavonoid Source | High Strength | Non-GMO, Gluten Free Supplement | No Artificial Preservatives | by Horbaach") £9.99

N-acetyl-cysteine (NAC) - supplemented.co.uk

COQ10 - [Powerful CoQ10 Complex - 300mg Max Strength,…](https://www.amazon.co.uk/gp/product/B095STZGW1/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A3PW5D6E7RX1ZZ "Powerful CoQ10 Complex - 300mg Max Strength, 120 Capsules | Boosted with Kale, Flaxseed, Garlic and More | High Absorption Naturally Fermented Co Enzyme Q10 for Heart Health and Energy | Made in UK") - Amazon £19.99

I haven't got turmeric or probutyrate yet (turmeric gives me headaches and probutyrate was crazy money for me.) Didn't get quercetin as I went overkill on rutin on and this is better form of quercetin I believe ultimately? I also didn't pick up Vit e - I need to look closer at that and buy some.

I've started taking all of the tablets pretty much immediately as I have them all previously with no adverse affects on their own in a bid to get on top of this in my excitement (I know I know stupid). So far so good, better formed stools, no bleeding yet (it's only been a week however) despite having more beer and burgers than ever (very hot weather - very rare for me. I must say I have tons more mental energy now, feel better in that sense but a bit early to tell.

Now for the list of questions (sorry):

Oral Mesalazine - is known apparently to cause loose stools ironically - when did you taper off - is it wise to? Should I be hitting myself with the mesalazine enemas too for a period just to get things well under control then just take the anti oxidants?

Exercise - I do intensive exercise a couple of times a week - I used to take vit c before but will change this to CAMU CAMU berry. What are your thoughts on Zinc L carnosine before exercise too (I have also heard that Vit c can kill off some of the benefits of exercise strangely).

Dark Chocolate - any good as a ROS anti oxidant? ANother one I love but gives me headaches in higher quantities.

Selenium - I'm thinking I'll add a few brazil nuts every day?

Any thoughts on Triphala powder as an antioxidant?

Thanks again - hopefully. smile
Posted 7/21/2022 11:53 AM (GMT 0)
Thanks VanJordan for the detail answer.
I still can't help but wonder why it suddenly appears 30 years into life though if its genetic and environment has been the same throughout? Something triggers an exponential amount of H202 that causes UC?

Personally I suffer from OCD and anxiety (which the OCD feeds daily). I stress out a lot about different things, health being a big one. I do see a therapist but I still suffer from it a lot.

I'm also on Humira, Imuran and rectal meds and lately not having much luck. Seem to be regressing after only 4 months on Humira.

Maybe I missed it though the whole thread, but is there a specific protocol to follow (supplements, foods to have and avoid) to get this H202 issue under control? I read your signature about antioxidants you use, is this up to date?

Could you provide a list of the name brand supplements you use? I would like to order the exact same ones.
(if this is against forum rules, I would appreciate it if you could DM the list).

Also are any of those antioxidant supplements likely to interact with my current meds (Adalimumab, Azathioprine)?

Thank you,
1Wish

Post Edited (1Wish) : 7/21/2022 5:24:43 AM (GMT-7)

Posted 7/21/2022 6:32 PM (GMT 0)
1wish, the second post on page 1 of this thread includes a summary of what VanJordan takes.

I'm definitely not an expert on this topic, but my understanding is other things in our lives can push our bodies over the tipping point. You can have lower levels of inflammation in your body for a long period of time without recognizing the issue. A stressful event, toxins in our environment, illness, certain foods, and a long list of other things can all be the final trigger to really set our bodies enough out of balance to recognize the diseased state / imbalance. For me, I took low levels of antibiotics for several years to control acne. This coupled with a bad relationship and some resulting stress, triggered my body. Each UC relapse I've experienced has also been the result of either emotional or physical stress (illness).

For me, the hydrogen peroxide theory and other information VanJordan has shared makes the most sense with my UC experience and the ways I have responded and not responded to treatment. I started his supplement plan (outlined on the first page) several weeks ago. I did not start the supplements slowly enough at first and experienced some gas and bloating. I quickly scaled back and have added one supplement per week. I am up to 4 supplements now and feeling great. I am still on Stelara, but currently appreciating the fact that things feel more 'normal' overall. My goal is to eventually get off of Stelara.
Posted 7/21/2022 7:12 PM (GMT 0)
IamCurious, you can't take intracellular enzymes orally. They don't survive stomach acid, and even if they did there is no way to get them inside of cells. SOD supplements are a gimmick. Intracellular enzymes are tightly regulated by gene expression and negative feedback mechanisms. They can't be increased through oral supplementation. This is the same reason why taking catalase doesn't work.
Posted 7/21/2022 7:18 PM (GMT 0)

lUvsoCcer said...
Hi VanJordan, first of all thanks for all the answers and posts in here - much appreciated. I've been reading old mike and co in here for many years so thanks also to those guys.
I really like the sound of this theory and many of the ideas seem to fit with how I have reacted personally over the years- for example red meat, dairy and alcohol are the three main triggers for me to avoid. I am on mesalazine tablets and enemas. The tablets keep things fairly quite but every few weeks I have to use the enemas to stop new bleeding in a constant cycle. Incidentally the bouts of bleeding seem to coincide every time with if I get a cold - could that fit with the theory somehow? I have been on holiday in the past at all inclusive resorts where you can eat anything and took this as a challenge to fill myself with as much healthy fruit and veg as possible (unsustainable at home) - these have been the only times in recent years my bowel movements have been great. - Is this possibly a likely combo of increased butyrate and antioxidants?
So on that note I've gone and bought a ton of supplements as follows (I'm UK based).:

Pomegranate extract - supplemented.co.uk -
**Pomegranate Extract (90% Ellagic Acid) 250mg Capsules - 180 - £11.**

Milk Thistle - Amazon - Milk Thistle Extract 7500mg - 80% Silymarin - £6.99

Grapeseed extract - supplemented.co.uk (tablets)

vitamin C: camu powder - [Superfood Outlet Organic Camu Camu Powder 1kg](https://www.amazon.co.uk/gp/product/B07VTMJQKG/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A1VXL2W0ZMJK3 "Superfood Outlet Organic Camu Camu Powder 1kg") £24.99, rosehip powder, or acerola cherry powder

Orange Juice and cherries consuming more of.

Rutin - 50-100mg/day - Amazon -[Rutin 500mg | 120 Vegan Tablets | Natural…](https://www.amazon.co.uk/gp/product/B08TQPVBD9/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A4GQDSVHXXKAQ "Rutin 500mg | 120 Vegan Tablets | Natural Bioflavonoid Source | High Strength | Non-GMO, Gluten Free Supplement | No Artificial Preservatives | by Horbaach") £9.99

N-acetyl-cysteine (NAC) - supplemented.co.uk

COQ10 - [Powerful CoQ10 Complex - 300mg Max Strength,…](https://www.amazon.co.uk/gp/product/B095STZGW1/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A3PW5D6E7RX1ZZ "Powerful CoQ10 Complex - 300mg Max Strength, 120 Capsules | Boosted with Kale, Flaxseed, Garlic and More | High Absorption Naturally Fermented Co Enzyme Q10 for Heart Health and Energy | Made in UK") - Amazon £19.99

I haven't got turmeric or probutyrate yet (turmeric gives me headaches and probutyrate was crazy money for me.) Didn't get quercetin as I went overkill on rutin on and this is better form of quercetin I believe ultimately? I also didn't pick up Vit e - I need to look closer at that and buy some.

I've started taking all of the tablets pretty much immediately as I have them all previously with no adverse affects on their own in a bid to get on top of this in my excitement (I know I know stupid). So far so good, better formed stools, no bleeding yet (it's only been a week however) despite having more beer and burgers than ever (very hot weather - very rare for me. I must say I have tons more mental energy now, feel better in that sense but a bit early to tell.

Now for the list of questions (sorry):

Oral Mesalazine - is known apparently to cause loose stools ironically - when did you taper off - is it wise to? Should I be hitting myself with the mesalazine enemas too for a period just to get things well under control then just take the anti oxidants?

Exercise - I do intensive exercise a couple of times a week - I used to take vit c before but will change this to CAMU CAMU berry. What are your thoughts on Zinc L carnosine before exercise too (I have also heard that Vit c can kill off some of the benefits of exercise strangely).

Dark Chocolate - any good as a ROS anti oxidant? ANother one I love but gives me headaches in higher quantities.

Selenium - I'm thinking I'll add a few brazil nuts every day?

Any thoughts on Triphala powder as an antioxidant?

Thanks again - hopefully. smile

This is really overwhelming to read. I'm not a physician and I can't manage every detail of your condition for you. It's up to you to experiment with the supplements and monitor your own reactions to them. All I can do is talk about Dr. Pravda's theory, how it worked for me, and the supplements I used to achieve that.

One thing I can answer is: yes, getting viruses can aggravate UC. Infections trigger inflammation and immune response. If the immune system and inflammatory factors are already active in the colon, then flooding the body with more of them could trigger the colon further. Also, febrile conditions cause increased thyroid activity in order to generate the necessary heat to fight infection. That heat is a result of cellular metabolism increasing, which means more hydrogen peroxide output.
Posted 7/21/2022 7:28 PM (GMT 0)

1Wish said...
Thanks VanJordan for the detail answer.
I still can't help but wonder why it suddenly appears 30 years into life though if its genetic and environment has been the same throughout? Something triggers an exponential amount of H202 that causes UC?

Personally I suffer from OCD and anxiety (which the OCD feeds daily). I stress out a lot about different things, health being a big one. I do see a therapist but I still suffer from it a lot.

I'm also on Humira, Imuran and rectal meds and lately not having much luck. Seem to be regressing after only 4 months on Humira.

Maybe I missed it though the whole thread, but is there a specific protocol to follow (supplements, foods to have and avoid) to get this H202 issue under control? I read your signature about antioxidants you use, is this up to date?

Could you provide a list of the name brand supplements you use? I would like to order the exact same ones.
(if this is against forum rules, I would appreciate it if you could DM the list).

Also are any of those antioxidant supplements likely to interact with my current meds (Adalimumab, Azathioprine)?

Thank you,
1Wish

Age 30 marks the beginning of aging and a slow decline of metabolic health. The regenerative (healing) capacity of the body is probably able to match the corrosive effects of hydrogen peroxide until then. It's the same reason why young people can get away with so much. Drinking, drugs, extreme sports, burning the candle at both ends. They still have metabolic resiliency to recover quickly, whereas older people would be wrecked. Youth masks a lot. Genetic vulnerabilities often don't reveal themselves until the onset of aging.

Age 30 is not hard and fast either. UC occurs at all ages, but it tends to occur most at the beginning of aging. It also depends on the body's oxidative status and antioxidant capability. If the genetics are not utterly horrid like mine are, maybe someone only gets minor UC, or they don't develop UC until they're 40 because the hydrogen peroxide assault is not as severe and their body can still cope until that point in their aging. Or maybe they just have a particularly strong constitution and their metabolic aging doesn't really kick in until 40.

Another factor is that a lot of people's UC begins with a trauma: emotional or physical. Mine started with the end of an important relationship. I've met many whose UC started after food poisoning. Gut injury increases the hydrogen peroxide problem a lot and then the inflammatory cascade starts. It's why even people with poor antioxidant genetics may not get UC... because they didn't get the critical injury to start the ball rolling. However, it's interesting to note that people with SOD or GSTP mutations are more prone to colon cancer. Hydrogen peroxide is not a direct carcinogen but when its concentrations get high, it can damage DNA through oxidation. Inflammatory cascade in of itself is carcinogenic though. So even without UC, poor antioxidant genetics are a determinant for cancers in parts of the body where oxidation status is high (i.e. distal colon).
Posted 7/21/2022 7:34 PM (GMT 0)

VanJordan said...
you can't take intracellular enzymes orally. They don't survive stomach acid, and even if they did there is no way to get them inside of cells. SOD supplements are a gimmick.

Right, but supplementing with chokeberry is not taking SOD directly. Chokeberry anthocyanins promote SOD production within your own body.
Posted 7/21/2022 7:41 PM (GMT 0)

VanJordan said...


Another factor is that a lot of people's UC begins with a trauma: emotional or physical. Mine started with the end of an important relationship. I've met many whose UC started after food poisoning. Gut injury increases the hydrogen peroxide problem a lot and then the inflammatory cascade starts. It's why even people with poor antioxidant genetics may not get UC... because they didn't get the critical injury to start the ball rolling. However, it's interesting to note that people with SOD or GSTP mutations are more prone to colon cancer. Hydrogen peroxide is not a direct carcinogen but when its concentrations get high, it can damage DNA through oxidation. Inflammatory cascade in of itself is carcinogenic though. So even without UC, poor antioxidant genetics are a determinant for cancers in parts of the body where oxidation status is high (i.e. distal colon).

This is interesting, because my UC started already with 23 after an intense lower ABS Workout. I never really could figure out, why this has triggered my UC, but here we have an explanation.
(I always wish, I would have skipped that training)
Posted 7/22/2022 12:50 AM (GMT 0)

IamCurious said...

Right, but supplementing with chokeberry is not taking SOD directly. Chokeberry anthocyanins promote SOD production within your own body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/

The body can absorb significant amount of bromelain; about 12 gm/day of bromelain can be consumed without any major side effects [13]. Bromelain is absorbed from the gastrointestinal tract in a functionally intact form; approximately 40% of labeled bromelain is absorbed from intestine in high molecular form [21]. In a study carried out by Castell et al. [13] bromelain was detected to retain its proteolytic activity in plasma and was also found linked with alpha 2-macroglobulin and alpha1-antichymotrypsin, the two antiproteinases of blood. In a recent study, it was demonstrated that 3.66 mg/mL of bromelain was stable in artificial stomach juice after 4 hrs of reaction and also 2.44 mg/mL of bromelain remained in artificial blood after 4 hrs of reaction [22].
Posted 7/22/2022 12:34 PM (GMT 0)
I feel like I'm stuck, my symptoms got worse over the last days and now I'm thinking about the forbidden fruit: Smoking. Do you guys think it would be a good idea to smoke for inducing remission? It should work as a potent hydrogen peroxid inhibitor.
Posted 7/22/2022 1:54 PM (GMT 0)

VanJordan said...

lUvsoCcer said...
Hi VanJordan, first of all thanks for all the answers and posts in here - much appreciated. I've been reading old mike and co in here for many years so thanks also to those guys.
I really like the sound of this theory and many of the ideas seem to fit with how I have reacted personally over the years- for example red meat, dairy and alcohol are the three main triggers for me to avoid. I am on mesalazine tablets and enemas. The tablets keep things fairly quite but every few weeks I have to use the enemas to stop new bleeding in a constant cycle. Incidentally the bouts of bleeding seem to coincide every time with if I get a cold - could that fit with the theory somehow? I have been on holiday in the past at all inclusive resorts where you can eat anything and took this as a challenge to fill myself with as much healthy fruit and veg as possible (unsustainable at home) - these have been the only times in recent years my bowel movements have been great. - Is this possibly a likely combo of increased butyrate and antioxidants?
So on that note I've gone and bought a ton of supplements as follows (I'm UK based).:

Pomegranate extract - supplemented.co.uk -
**Pomegranate Extract (90% Ellagic Acid) 250mg Capsules - 180 - £11.**

Milk Thistle - Amazon - Milk Thistle Extract 7500mg - 80% Silymarin - £6.99

Grapeseed extract - supplemented.co.uk (tablets)

vitamin C: camu powder - [Superfood Outlet Organic Camu Camu Powder 1kg](https://www.amazon.co.uk/gp/product/B07VTMJQKG/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A1VXL2W0ZMJK3 "Superfood Outlet Organic Camu Camu Powder 1kg") £24.99, rosehip powder, or acerola cherry powder

Orange Juice and cherries consuming more of.

Rutin - 50-100mg/day - Amazon -[Rutin 500mg | 120 Vegan Tablets | Natural…](https://www.amazon.co.uk/gp/product/B08TQPVBD9/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A4GQDSVHXXKAQ "Rutin 500mg | 120 Vegan Tablets | Natural Bioflavonoid Source | High Strength | Non-GMO, Gluten Free Supplement | No Artificial Preservatives | by Horbaach") £9.99

N-acetyl-cysteine (NAC) - supplemented.co.uk

COQ10 - [Powerful CoQ10 Complex - 300mg Max Strength,…](https://www.amazon.co.uk/gp/product/B095STZGW1/ref=crt_ewc_title_oth_1?ie=UTF8&psc=1&smid=A3PW5D6E7RX1ZZ "Powerful CoQ10 Complex - 300mg Max Strength, 120 Capsules | Boosted with Kale, Flaxseed, Garlic and More | High Absorption Naturally Fermented Co Enzyme Q10 for Heart Health and Energy | Made in UK") - Amazon £19.99

I haven't got turmeric or probutyrate yet (turmeric gives me headaches and probutyrate was crazy money for me.) Didn't get quercetin as I went overkill on rutin on and this is better form of quercetin I believe ultimately? I also didn't pick up Vit e - I need to look closer at that and buy some.

I've started taking all of the tablets pretty much immediately as I have them all previously with no adverse affects on their own in a bid to get on top of this in my excitement (I know I know stupid). So far so good, better formed stools, no bleeding yet (it's only been a week however) despite having more beer and burgers than ever (very hot weather - very rare for me. I must say I have tons more mental energy now, feel better in that sense but a bit early to tell.

Now for the list of questions (sorry):

Oral Mesalazine - is known apparently to cause loose stools ironically - when did you taper off - is it wise to? Should I be hitting myself with the mesalazine enemas too for a period just to get things well under control then just take the anti oxidants?

Exercise - I do intensive exercise a couple of times a week - I used to take vit c before but will change this to CAMU CAMU berry. What are your thoughts on Zinc L carnosine before exercise too (I have also heard that Vit c can kill off some of the benefits of exercise strangely).

Dark Chocolate - any good as a ROS anti oxidant? ANother one I love but gives me headaches in higher quantities.

Selenium - I'm thinking I'll add a few brazil nuts every day?

Any thoughts on Triphala powder as an antioxidant?

Thanks again - hopefully. smile

This is really overwhelming to read. I'm not a physician and I can't manage every detail of your condition for you. It's up to you to experiment with the supplements and monitor your own reactions to them. All I can do is talk about Dr. Pravda's theory, how it worked for me, and the supplements I used to achieve that.

One thing I can answer is: yes, getting viruses can aggravate UC. Infections trigger inflammation and immune response. If the immune system and inflammatory factors are already active in the colon, then flooding the body with more of them could trigger the colon further. Also, febrile conditions cause increased thyroid activity in order to generate the necessary heat to fight infection. That heat is a result of cellular metabolism increasing, which means more hydrogen peroxide output.

Apologies VanJordan for the overwhelming amount of stuff above I should have been more concise, I put it in there to maybe help the overall picture of this theory. I didn't mean this to turn into a patient and physician session haha. Thanks though for your considered response.

One question then - timings of supplements? Does it matter - around exercise - around food? I could never find a definitive answer for mesalazine with or without food?

Thanks
Posted 7/22/2022 3:02 PM (GMT 0)

Pinocchio said...
I feel like I'm stuck, my symptoms got worse over the last days and now I'm thinking about the forbidden fruit: Smoking. Do you guys think it would be a good idea to smoke for inducing remission? It should work as a potent hydrogen peroxid inhibitor.


I don't think that's a good idea. Are you taking any medication for your UC?
Posted 7/22/2022 3:34 PM (GMT 0)

poopydoop said...

Pinocchio said...
I feel like I'm stuck, my symptoms got worse over the last days and now I'm thinking about the forbidden fruit: Smoking. Do you guys think it would be a good idea to smoke for inducing remission? It should work as a potent hydrogen peroxid inhibitor.


I don't think that's a good idea. Are you taking any medication for your UC?

Medication never really worked for me, I even felt like it made me worse. Remicade did a bit, but I dont really wanna go back to Biologicals, they scare me. I'm not in a bad flare, but this one is nearly going on for 2 years. I feel like, I'm missing out on my youth.
I will try smoking ~3 cigarettes a day and see, if this can reduce the hydrogen peroxide production. Already had some success with my supplements.
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