Niacin and Colitis PGD2

Thought I would bring this up again,there was some old 2011 info,this is a refresh.
CAUTION: Can raise blood glucose,might cause diabetes.
Oldmike

https://www.pnas.org/doi/10.1073/pnas.1004982107
https://www.embopress.org/doi/full/10.15252/emmm.201606987

niacin and butyrate GPR109a
https://www.sciencedirect.com/science/article/pii/s1074761313005645
more interesting il-10 levels normal with niacin
https://pubmed.ncbi.nlm.nih.gov/28769047/
more pgd2
https://pubmed.ncbi.nlm.nih.gov/20547854/
iga and GPR109a niacin activates along with butyrate

https://www.frontiersin.org/articles/10.3389/fimmu.2020.583652/full

il-23

https://www.jimmunol.org/content/200/1_supplement/43.18

more
https://www.sciencedaily.com/releases/2014/01/140116113510.htm


https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00543.2011
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4305274/#:~:text=at%20these%20high%20doses%2c%20niacin,suppressive%20effects%20in%20the%20colon.

just storing this here on taurine
https://www.biomolther.org/journal/view.html?volume=26&number=3&spage=225&year=2018

NAD+ UC mitochondria
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc9385040/

more
https://www.sciencedirect.com/science/article/pii/s221323172200009x

Interesting! Some stuff on lipid peroxidation with niacin here:

https://clinmedjournals.org/articles/jnmdc/journal-of-nutritional-medicine-and-diet-care-jnmdc-2-014.php#:~:text=the%20results%20of%20the%20reviewed,peroxidation%20and%20reperfusion%20oxidative%20injury.

What’s interesting to me is NO is an oxidative molecule, and a vasodilator, but ulcerative colitis often shows abnormal vascular patterns, or the absence of them. Not to go too far off track, but this article explains some of the oxygen sensing mechanisms that may control vascularity in the colon.

I’ve been wondering how an environment that thrives in hypoxia fairs when people swallow a lot of air, like me with CPAP therapy.

https://mdpi-res.com/d_attachment/ijms/ijms-22-09170/article_deploy/ijms-22-09170-v2.pdf?version=1629944319

Mike,

Looking into mtDNA damage and repair. Interesting articles:

GSH-EE can replenish mitochondrial GSH. NAC increases GSH, but falls short of replenishing the mitochondria.

https://www.sciencedirect.com/science/article/pii/s2213231716302567
edit: link fixed

Post Edited (LowLead) : 8/30/2022 11:30:52 PM (GMT-7)

Clo, sounds good. I'd be interested in that.

Mike, have you ever had an inflammatory bowel disease serology panel ran? It's a blood test that detects pANCA, and ASCA antibodies, which are commonly found in IBD patients.

I tested positive for ASCA IgG antibodies, which is an antibody to saccharomyces cerevisiae (brewer's yeast).

Interestingly, saccharomyces cerevisiae yeast is a source of alpha lipoic acid (ALA). (https://www.onnit.com/academy/alpha-lipoic-acid-benefits-uses-side-effects/).

Immunity to ALA may help explain why reduced forms (RDLA) are critical.

Old Mike said...

lets get confused

I think I took this literally, Mike ;-)

Dropping you a few more links on Saccharomyces cerevisiae. Let me know if this is old news.

Saccharomyces cerevisiae converts superoxide to H2O2:
https://www.frontiersin.org/articles/10.3389/fonc.2012.00064/full

Anti Saccharomyces cerevisiae antibodies are found in 57 percent of CD patients, and 19 percent of UC patients:
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc1808965/

Magnolol protects Saccharomyces cerevisiae mutants deficient in antioxidants from death:
https://academic.oup.com/femsle/article/366/8/fnz065/5423324

Putting it all together:
Diarrhea and rectal bleeding in DSS-induced mice were significantly attenuated by magnolol treatment, accompanied by recovered body weight loss, comparable with infliximab administration.
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6152296/

Post Edited (LowLead) : 9/1/2022 5:31:57 AM (GMT-7)