Entyvio trough levels

Has anyone had experience with Entyvio trough levels. Mine were 12 post 8 week infusion. Not sure of the units here but think these were standard. The nurse called them "not too bad". From what I understand this is borderline low and might indicate a problem. Antibody levels were fine and CRP and Calprotectin normal.

Thanks

"Potential target vedolizumab/entyvio trough levels were 37.1 μg/mL at week 6 during induction, 18.4 μg/mL at week 14 after induction, and 12.7 μg/mL during maintenance treatment"

"Data from the two largest available real-world cohorts to date confirmed a link between higher vedolizumab exposure and achieving better outcomes"

"Belgian study, vedolizumab/entyvio trough levels > 30 μg/mL at week 2, > 24 μg/mL at week 6, and > 14 μg/mL during maintenance therapy, correlated with higher clinical and endoscopic effectiveness endpoints in IBD patients"

Source: Vedolizumab trough level monitoring in inflammatory bowel disease: a state-of-the-art overview

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6505179/

It depends on doctor. Some use patient reported symptoms before versus during treatment as the primary indication of success, only using the labs when it's paradoxical, loss of response after success, etc.

Some docs want to draw labs at every infusion.

How are you doing? Have you had improvement in your symptoms and quality of life? If you haven't had any improvement at all then the trough level could be concerning. If you are doing well, then I wouldn't worry about it.