Possible reason why women suffer autoimmune more than men

https://wapo.st/48ZcG1q

Yet, UC is actually more common in men than women

Do you have published research or links to back that up poppydoop? Nowhere have I seen it quoted that IBD / UC / CD is more common in one gender group than the other (in my view there are two such groups).

I agree with beave. IBD does not distinguish by gender or select by such. I also agree that diseases like lupus, MS and RA are 3fold- 9fold more common in women than men. The research I have seen suggests that hormones play a big part in this.

D

Here you go. Feel free to critique...

https://www.sciencedirect.com/science/article/abs/pii/s0016508518346857

Those diff in rates for men and women are quite small. Ud wonder sbout statistical significance in such a study on a single cohort. Nowhere near the 3-9 fold differences you see with rheumatic disease for women.

The study has not changed my opinion thst IBD does not select by gender. Possibly location and age are confounding variables here along with smoking status giving an age selective effect.

Nothing to write home about on thst study

A Google search of "ulcerative colitis men women" shows multiple studies, with some saying prevalence is about the same, others showing slightly more men than women, and others specifying that rates are about the same until elderly years, where rates for men overtake women.

Crohn's and Colitis Foundation (USA): "In general, IBD affects men and women equally. However, most North American studies show that ulcerative colitis is more common in men than in women."

Crohn's and Colitis Foundation (USA) Regarding UC: "Men and women are equally likely to be affected, but older men are more likely to be diagnosed than older women."

The Lancet: "Ulcerative colitis has similar prevalence in men and women, although some studies suggest it is slightly more common in men."

NIH Study: "Generally speaking, males and females demonstrated similar incidence of UC before age 45; however, above age 45 years, males demonstrated higher..."

Temple Health: "Women are more likely to develop Crohn's disease than men, but more men develop ulcerative colitis than women. Even though the average age of developing IBD is between 15 and 35, more men are diagnosed with ulcerative colitis in their 50s and 60s than women of the same age."

NHS (Great Britain): "Both men and women seem to be equally affected by ulcerative colitis."

So I don't think this is much to argue about. As I said before, it might no be exactly 50-50 men-women, but it's nowhere near the unbalanced prevalence seen in certain other so-called autoimmune conditions.

Most autoimmune diseases affect women much more than men, but with IBD there is very little difference between men and women. So I wonder if IBD isn't really a true autoimmune disease.

Maybe IBD is caused by a mycobacteria similar to paratuberculosis which is the causative agent of Johne's disease in cows, which resembles Crohn's disease in humans.