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How long did Remicade/Humira take to work?

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Posted 7/10/2008 3:53 AM (GMT 0)
Hi All,

I need to know two things:
- How long did your Remicade/Humira take to work?
- What dose were you on per Kg of body weight?

Really need to know both of these things as I am on a Humira like drug and can't find ANY information on the net at all with regard to how long its supposed to take to work!!!!

I have severe pan-colitis and my doctor recons I should have noticed a change within 3 days of my sub-dermal injection. Is this right???

Thnx,
--Sev
Posted 7/10/2008 1:01 PM (GMT 0)
Severin, I don't know that you can compare to Remi because of the different method of delivery. The usual dose is 5 mg./kg. every 8 weeks. It can be increased as high as 10 mg./kg. and/or given as frequently as 6 weeks. My induction was infusions at one, three and six weeks. I could tell a definite difference after the second infusion.
Posted 7/10/2008 2:26 PM (GMT 0)
I asked a similar question regarding Remicade a little while back:

https://www.healingwell.com/community/default.aspx?f=38&m=1157636


As for me, I just received my third infusion the other day (had them at 0, 2, and 8 weeks). My symptoms have certainly improved, although I am still in a flare-up.
Posted 7/11/2008 1:56 AM (GMT 0)
I am very much also chasing info on those using Humira. I really think my GI's optimism that I should feel better within 3 days is a bit over the top. Everything I have read on this forum in the past suggests that it usually takes around 2 infusions to really have any major change...
Posted 7/11/2008 3:47 AM (GMT 0)

I've had 2 infusions of Remi so far and have not improved much. I don't have as much of an urgency problem--I can walk to the bathroom instead of run. I've had about one good day per week (little blood, about 4 BMs) since starting Remi, but the rest of the days are "normal" flare days. sad I'm not sure what my dose is.

Some people start feeling better after the first infusion--maybe that's why your GI is saying w/in 3 days? Have you noticed even any small changes?

Posted 7/11/2008 7:22 PM (GMT 0)
I kid you not, I felt results within the first 24 hours of my first infusion, at 5mgs/kg dose , every 8 weeks. I was able to sleep thru the night, finally, & went down to about 4-6 formed bm's, no blood. Which sounds like a lot, but was a VAST improvement over my previous 10-15 bm's a day. Worked alright for a little less than a year, aside from horrible strep pneumonia complications, but after my first few infusions the results were lessened. And my symptoms were coming back sooner & sooner. Am now at 10mgs/kg dose, every 6 weeks. Is working alright- I have 4-7 bm's a day, no blood (well, maybe a little bit in the week before my infusion), & am usually able to sleep thru the nights. Or get up only once.

Posted 8/26/2008 3:19 AM (GMT 0)
After having severe pan colitis I have had 3 infusions since June 08.  I was feeling 95% within a few days of the first infusions and continued to be well after the second, until I received a stomach flu with diaherra in early July.  While everyone at work recovered within 24 hours, I got continuously worse until my third infusion in late July.  My progress after that infusion was a slow and gradual improvement (not as quick as the first time)...it was all looking good until the flu hit the office again.  I am trying to hang in until the 4th infusion Sept 19th.  I am not as bad as after the first flu. The nurse told me it takes 4-5 infusions and I can likely try to get pregnant after 6-8 infusions.  I am hopeful as we'd like to have another baby.  Good luck to all of you.  Let me how long it took for you to  go into remission with remicade.  Thanks! 
Posted 8/27/2008 11:28 AM (GMT 0)
I've been on Humira since 1/01/08. If I remember correctly, my GI had me on it for two months before having me start reducing other meds.
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