UC and English descent

     Was just wondering.......I noticed some of the people in this forum are from the UK, Canada and Australia.  I am an American but dad was English descent (but family in US since 1600's) and it is from dad's family that I inherited this nasty disease..UC.  Any studies done to link UC and the UK?

Well, I'm English and living in Canada, and from what research I've seen, there is a deffinately link to Western, developed countries....

I think it's the human body saying 'no more' to all the processed foods, pollutants and radio waves that we subject it to here in the 'developed' world....what do you reckon??

I have a lot of English in my ancestry too. I also noticed a lot of Canadians and UK folks on the line.

I am English and German and live in America.

Most of the current legit research I have read lately concerning UC has come from Canada.

I'm Canadian..born and raised.  My paternal grandparents were from Scotland and my maternal grandparents were from Poland.

I have crappy genes, basically.

q

UC is very common amongst Indians.

Maybe it's because British soldiers raped Indian women during rthe British rule of India

I believe overall Canada has the highest incidence of IBD per capita...I'm Canadian and live in Alberta which for the longest time was the leading province for IBD, recently Nova Scotia has been winning that race over AB. IBD now a days is becomming more prevalent world wide though, africa, china, ect, places where it was virtually unheard of and they suspect it may have something to do with those places becomming a little more westernized especially when it comes to food.

:)

The latest medical thinking is that IBD has something to do with Northern climes-- less exposure to sun, less vitamin D over generations leading to genetic mutation-- that kind of thing, resulting in higher rates of illness in UK, Netherlands, Iceland, Canada, for example. That's what they got from 1990s epidemiology, I think. However, higher numbers of cases reported in India, Japan, & the Philippines seem to support theories of overdevelopment involving technology, changing food supply, etc. More on this will be published in the coming year; two U.S. gastroenterologists will soon publish a book called The Changing World of IBD, which deals with genetic & environmental issues, among other subtopics. / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

Crohn's disease/UC is found throughout the world. However, it appears to be most common in North America and northern Europe, and Canada has one of the highest incidence rates in the world. Crohn's affects more than 800,000 people in North America. The highest prevalance to IBD is with those from jewish descent.


:)

I am from Canada. My father's side of the family is from out east (NFLD) and has some English and possibly scottish descent I believe. Not sure about my mom's side, all from Ontario for quite some time. Only UC in my family is my dad's Aunt, who has been in remission for years. I'm the first lucky one in my family to carry it on I guess.

I have also heard about the northern climates being affected, but there has also been studies showing how heart disease and IBD are almost non-existent in far north climates such as greenland where they eat a diet high in fish and healthy fats as opposed to processed crappy food. I think it is showing that western food is a killer.

Old Hat, I highly doubt the relation of jewish descent and IBD will be debunked as more studies show from 2008...

Results shed light on special genetic vulnerabilities of Ashke**** Jews

What is believed to be the largest study of its kind for the genetic roots of inflammatory bowel diseases has suggested new links to Crohn’s Disease as well as further evidence that some people of Jewish descent are more likely to develop it.

The study examined changes in DNA associated with the two most common forms of inflammatory bowel disease (IBD): Crohn’s Disease (CD), which is most frequently marked by inflammation of the final section of the small bowel (ileum) and parts of the colon, and ulcerative colitis (UC), an inflammation of the internal lining of the rectum and colon.

Results of the study, published in this month’s edition of Genes and Immunity, included information gleaned from 993 families with IBD, 244 of whom were Ashke**** Jews. Up to 30 percent of people with IBD in the United States are estimated to have a family history of the condition, and about 25 percent of these families have both CD and UC in the family. People of Ashke**** Jewish descent are at least twice as likely to develop a form of IBD and are more likely to have familial disease.

“This increased risk for some Jewish people makes our study and results especially significant since this is the first sample size of Jewish families, 244, that was large enough to identify novel gene regions for familial predisposition in this ethnic group,” says Johns Hopkins gastroenterologist and genetic investigator Steven R. Brant, M.D., senior author of the study.

By analyzing common DNA variations known as single nucleotide polymorphisms, or SNPs, the team found evidence for genes causing familial Crohn’s Disease in the study population specific to Ashke**** Jewish families with CD on previously identified areas of chromosomes 1 and 3. They also identified a never-before-identified region of chromosome 13 that was shared by both Jewish and non-Jewish families with CD. Evidence for chromosomal regions that may be linked to UC on chromosome 2 and 19 for Jewish and non-Jewish families was also noted, according to Brant.

“What makes these results especially significant is not only the large sample size but also the method we used for screening, namely the use of a high-density, single-nucleotide polymorphism genome-wide linkage process, says Brant.” The new process is 10 times faster than older methods at searching the number of variations across the genome, he added.

Up to now, Brant says, no gene regions implicated in IBD were specific to Ashke**** families, and genetic evidence pointing to why Ashke**** Jews are twice as likely to get the disorder was lacking. The two genetic regions identified on chromosomes 1 and 3 were specific to Ashke**** CD and unrelated to known IBD genes.

Although further study is needed to narrow down which specific genes are the major players, Brant says it’s already clear that they are in the right “neighborhood” to search for IBD/CD susceptibility genes.

:)

The info about jewish descent doesn't mean you have to be jewish in order to get an IBD, it just means that of all the races, jewish people have a higher tendancy to get an IBD but not all jewsish people will or do get it either.

:)

I'm only going by all the research past and present that I've read regarding the relation to higher prevalance with those of jewish descent...it has no more to do with those that are not of jewish descent that do have an IBD it's simple research that shows those of jewish descent do have a higher tendancy to get an IBD and as I already mentioned it doesn't mean every jewish person will or does have it. It is was it is.

:)