It is interesting. Quite a few pubmed abstracts on mast cells role in IBD e.g. this review article:
http://www.ncbi.nlm.nih.gov/pubmed/14760748?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed
Of course, the role of mast cells is far more complex in IBD than histamine, since anti-histamines have no effect against IBD inflammation.