Sorry, I don't have the answer to your questions, just an observation that when I get up in the night (I usually have to get up to pee and also to walk around a bit to ease the arthritis)) I have that horrible gas and some of the mesalamine goes with it. I'd used mes. eneams years ago on and off, but then just restarted them a few weeks ago, so I'm sure the gas is a result of the enemas.
I figure some of the medication stays in, so I'm not worried about
that...
I am trying to go to bed 1/2 hour earlier to make up for my nighttime wanderings and contribution to the earth's gas stores
, but I know that's not practical for everyone.