Not responding to prednisone?

I started my pred. Friday and for the first two days I was pretty OK all day and then evening started in with D that came all night then early morning starting 4ish am I'd have horrible pain and D until (and for a couple hours after) my next dose around 7am. After 2 nights of that I started splitting my dose. I don't feel AS good during the day but I'm getting some sleep at night now. So now I feel bad for 1-2 hours before each dose but to me it's better than the crazy 3-6 hours of agony and no sleep thing that was happening with 1 dose. I have not talked to my doctor about this yet (going to try and get him on the phone today) so I'm not 100% sure he's not going to be mad. However, I felt like at the time my choices were to try a split dose or pack for the hospital.

I suspect whats happening in cases like ours is that we're just completely metabolizing the dose by evening. It makes sense that people would kick the stuff out at different speeds. Call your doctor! A splitting the dose is helping me. I suspect I'll pay for it somehow later though!

First time on pred in my whole life for me, so it's not a resistance thing here but I have always been pretty resistant to drugs. Like when I had my scope last week the nurse put the drugs in, looked me, put more in, waited. Looked bewildered, put more in. It's like trying to put down a large animal and I'm really not even that big. :o)

At lot of people thought my dosing was crazy, but my doc had me split my dose. When I was on 40mg, I took 10mg at breakfast, lunch, dinner, and bedtime. When I went down to 30 mg, I dropped the bedtime dose, at 20 mg, I only took it at breakfast and lunch. When I was at 15mg and below, I took it all with breakfast. It worked well for me.

I guess I will try splitting tomorrow and see how that works. I've just never had this issue before...40 mg of pred has always started to knock my flares out pretty quickly.

I agree about trying to split the dose. I have only been on pred twice. The first time it did take about two weeks to kick in.

Is the rowasa you take at night an enema? For me sometimes the enemas do more harm than good. I have experimented and found that sometime they actually make me have to get up and go more times during the night than when I don't take them...seem to have a laxative effect for me sometimes...if you are taking the enemas and if you are comfortable with it you might try skipping them for a few nights or switching to a suppository...

We may be twins! I'm in the same boat. I take mine in the morning to sleep better with the stupid pred insomnia...not that it helps much becuase i'm still up all night with diarrhea...splitting the dose may be a good plan.

Malkavian - when I was splitting my dose I took some benedryl at night which helped me sleep...might be worth a try. I understand about being lazy with the enemas, they are so not fun!