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Starting Lialda

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Ulcerative Colitis
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Posted 6/24/2010 12:40 PM (GMT 0)
Went to the GI yesterday.  I asked him about Lialda again.  He never wanted to take me off the Asacol.  Been on it 8 years and it is obviously not working.  So we did switch to Lialda.  Instead of 12 pills a day I will only take 4.  Has anybody had any luck on Lialda?  I am hoping it will help.  I am also back on the Rowas at night.  I have been able to keep it in every night this week.   I will use the Canasa in the morning.

I am really hoping these changes along with the weekly Humira will do the trick.  I am down to 25mg of Pred this week and can tell a difference from being up higher.  I can't wait to be off it though.  Only started for the pregnancy and now that is gone.

I also got him to write the script for the VSL#3 DS.  Insurance still won't pay. 

Posted 6/24/2010 1:53 PM (GMT 0)
You never know, it could help. Someone else on here is going to try a sulfa. I hope everything works for you and you start feeling better.
Posted 6/24/2010 2:30 PM (GMT 0)
I tried to switch from Asacol to Colazal and then to Lialda. It seemed like after Asacol stopped helping, none of those drugs helped very much. I do think the Colazal helped with the bleeding more than Lialda but it wasn't stopping the flare, I still had loose stools and other symptoms.
Posted 6/24/2010 2:40 PM (GMT 0)
I have never been on anything other than Lialda but it does help me greatly. If I stop taking it I can tell a huge difference.
Posted 6/24/2010 4:13 PM (GMT 0)

I really hope the Lialda helps. Worth a try.

No relief yet even from going to weekly Humira shots.

I just had a few weeks of relief from being on the Prednisone.  Even now I can tell I am tapering.  I am on 25mg this week and am going down hill.

Looks like my beach vacation in July is going to suck.  House with bathroom is on the bay side.  Two block run to the bathroom is going to be tricky.

Posted 6/24/2010 4:42 PM (GMT 0)
I am on Lialda and it works for me ... well enough that I am on a maintenance dose of 1 a day (2 if it is PMS time)

As far as your trip ... you may want to consider what I did for a camping trip while I was coming off a flare. We were not close to the bathrooms so my hubby rigged an outdoor toilet area for me. The camping section of some outdoor stores may have a "pop-up" enclosed canopy structure that can be used for showers or bathrooms. We did something like this and purchased an inexpensive camp toilet which was basically a bucket with disposable bags and a seat on the top. A stall can be rigged too if you have something to serve as a base like a pop-up canopy or large beach umbrella. With a large tarp and some huge clamps, you can make a homemade enclosure.
Posted 6/28/2010 2:14 AM (GMT 0)
I have been taking 4 per day for about a year and a half. Other than the high cost, it has worked out well.

Good luck.
Posted 6/28/2010 4:12 AM (GMT 0)
I've tried Asacol, Colazal, and Lialda. None of them seem to help. At first I thought that they might have helped, but then after some experimentation I found out it was the Canasa suppositories that helped, not the mesalamines. This is not surprising, considering that my flares start at the rectum near my butt hole. What is surprising is that my GI recommended my taking mesalamines for life. He did not mention anything about using Canasa suppositories for maintenance. I think he feels that suppositories might not go far enough up the colon, but mesalamines don't go far enough down. Plus, they harm the liver.
Posted 6/28/2010 4:16 AM (GMT 0)
subdued, Canasa IS a mesalamine in suppository form. I guess you mean the pills? All mesalamines (5ASA) are topicals....

For those who are sensitive to salicylates, mesalamines may affect their liver. They do NOT go through a first pass as do systemic medications, a very small amount is in the bloodstream and will eventually go through the liver...again, a small amount.

Methinks you're a bit unclear on the mesalamine info....
q
Posted 6/28/2010 2:49 PM (GMT 0)
The systemic absorption of mesalamine pills is 20-30% in testing. There is a lot of variation in the brand names. Not exactly a small amount especially if you are on the larger oral doses and butt meds being used today. Lialda is 21% Asacol 28% Canasa(supp) is highly variable between 15-87% passing in urine.







www.ncbi.nlm.nih.gov/pmc/articles/PMC1773399/



www.rxlist.com/canasa-drug.htm
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