I use Primal Defense (PD) on and off a lot along with many other probiotics, in spite of the fact that the company founder's personal testimonials seem very fishy and made up to me, and he got in trouble years back for making some phony claims about
his credentials. That said, I have found PD to have some benefit (certainly it doesn't cause me any problems) in helping reverse flares, and therefore I mix it in my daily regimen along with others including VSL3, Align, Culturelle, Digestive Advantage IBS capsules, Reuteri Pearls, etc..