Love Humira- have been on it now for just over a year, with much better results than Remicade. I took Remicade for about
3 years, & it gradually lost effectiveness. So far, the Humira is still quite effective, I love the bi-weekly dosing schedule, & my UC symptoms are pretty minimal these days. I don't find my injection site to be too sore, I use my abdomen all the time. The leg HURTS, way more then the abdomen. The one time I did shoot myself in the leg, it hurt like mad for a day or so. Try the abdomen next time, I know the thought makes you cringe, but it's really far easier than the leg. Good luck!