"Excessive nitric oxide (NO) production by an isoform of NO synthase that can be induced by inflammatory stimuli leads to changes in vascular permeability and to tissue injury. "
That sounds like NO is bad. My morning pre-workout supplement NO*Explode creates a lot of NO. I never consumed this before getting UC 5 years ago - I wonder if it is contributing to UC ?
OK I spent a few more minutes on this. They say this was beneficial to mice with induced UC but the dose is important and how do we interpolate to a correct dose for humans ?
From the link above:
"The beneficial effect of exogenous NO supplementation
was observed in only a very narrow dose range (0.1 to 1 mg/kg/day), with lower or higher doses being ineffective. This may explain the apparent discrepancy between our results and those of Wallace et al (1999) showing that an aspirin derivative that releases NO over a prolonged period of time did not affect the severity of trinitrobenzene sulfonic acid-induced colitis. Differences between the two studies in the model of colitis and the NO donor molecule used might also explain the discrepant observations."
And this:
" From these findings, we conclude that in this chronic, spontaneous model of colonic inflammation, administering iNOS inhibitors with this treatment regimen did not provide any major therapeutic benefit."
Leaves me still wondering if NO supplementation is good or bad. I will have to just cut it out for a while and conduct my own test. I do not recall this being a magic cure in the past but given the connection with UC I might as well.
jpet.aspetjournals.org/content/280/2/1008.shortLooks like someone already did the heavy lifting for me:
forum.bodybuilding.com/archive/index.php/t-111148211.htmlSupplemental arachidonic acid and/or NO products --> and they're relation to IL-1 expression in Crohn's and Ulcerative colitis:
"While I am by no means a doctor, the literature that I have viewed leads me to believe that the systemic upregulation of AA may stimulate the IL 1-induced inflammatory response. IL-1b is a proinflammatory cytokine and it's overexpression increases intestinal epithelial Tight-Junction permeability, and magnifies the central role for IL1-induced intestinal inflammation amplification. Once the integrity of the epithelial barrier is compromised, issues such as parasite entry into mucosal tissues may also become evident.
Curcumin, resveratrol, EGCG, ect. have displayed therapeutic inhibition of IL-1 release, so ask your doctor if he feels if those nutrients would serve as useful additions to your supplement protocol (if they are not already).
BTW,
the use of NO products could possibly exacerbate the IL-1 response, thereby worsening the condition. http://forum.bodybuilding.com/showpost.php?p=141919951&postcount=122
Circumin and/or resveratrol are powerfull compounds that have been shown to effectively inhibit the pro-inflammatory protein NF-kB, which is amongst other things, is responsible for inflammation-induced tumor growth.
Post Edited (aguywithuc) : 2/11/2011 8:23:34 AM (GMT-7)