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Arginine Ethyl Ester

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Posted 8/20/2011 7:46 PM (GMT 0)
This version of L-arginine does not break down in the small intestine and does not cause problems in the GI tract. Far less is needed than regular L-arginine.

Has anyone else tried this ? It has a profound effect on my UC. Taking it every day now.

www.ncbi.nlm.nih.gov/pubmed/12851871

"Human intestinal microvessels from chronically inflamed IBD show microvascular endothelial dysfunction, characterized by loss of NO-dependent dilation that may contribute to reduced perfusion, poor wound healing, and maintenance of chronic inflammation."

In these study they use a different arginine variation (L-NAME) which is not my point. The point is that however they got some into the test subjects they were not able to force dilation using it as they were with the normal subjects. Blood flow is reduced, healing is reduced.

"Intact submucosal arterioles from control, involved, and uninvolved IBD specimens were assessed using in vitro videomicroscopy to assess endothelium-dependent vasodilation in response to acetylcholine (Ach) and fluorescence microscopy to detect oxyradicals. Normal microvessels dilated in a dose-dependent and endothelium-dependent manner to Ach (maximum, 82% +/- 2%; n = 34). Inhibition of nitric oxide synthase with N(G)-nitro-L-arginine methyl ester (L-NAME) reduced maximal dilation to 54% +/- 6% (P < 0.05, n = 7), and further reduction was observed after inhibiting cyclooxygenase (indomethacin; 23% +/- 10%, n = 6). Chronically inflamed IBD microvessels showed significantly reduced Ach-induced vasodilation (maximum, 15% +/- 2%; n = 33), with no effect of L-NAME. Indomethacin eliminated the remaining Ach-induced vasodilation, resulting in frank vasoconstriction (-54% +/- 9%, n = 6). Uninvolved IBD gut vessels and non-IBD inflammatory controls responded in a fashion similar to normal vessels. IBD-involved microvessels generated significantly higher levels of reactive oxygen species compared with control and uninvolved IBD vessels (P < 0.01)."


Other study suggesting we might benefit from supplementing L-arginine

www.labome.org/grant/r01/at/immunomodulatory/effects/immunomodulatory-effects-of-arginine-supplementation-in-colitis-and-colon-cancer-7811659.html


"As a supplement to our Parent R01, we propose to test the hypotheses that there is a functional deficiency of L-Arg availability in UC, and that dietary consumption of L-Arg may be a determinant of L-Arg availability and disease activity.

In addition to our funded studies under R01 AT004821 studying the importance of the amino acid L-arginine (L-Arg) in animal models, we have exciting new data in humans with ulcerative colitis indicating that there is accumulation of L-Arg in the serum of patients with severe UC, which suggests that there may be a defect in utilization of L-Arg in this disease."

Post Edited (aguywithuc) : 8/20/2011 1:54:28 PM (GMT-6)

Posted 8/24/2011 3:22 AM (GMT 0)
Adding to the permanent record for L-Arginine...

www.ncbi.nlm.nih.gov/pmc/articles/PMC2408412/figure/F8-7628/

"NF-κB binds to a specific consensus sequence and positively regulates the transcription of several genes involved in immune and inflammatory responses (cytokines, MMPs). l-Arginine could act on these cascades that lead to decreasing the active cytoplasmic NF-κB level and in consequently its transcriptional activity"

Arginine Decreases Inflammation - at least in muscles, maybe the gut too. Does so in a way that involves the immune system.

"Decreased Proinflammatory Cytokine and Infiltrating Macrophage after Treatment"

Arginine Elsewhere..

For congestive heart failure: doses range from 6-20 grams per day, as three divided doses.
For chest pain associated with coronary artery disease (angina pectoris): 3-6 grams three times per day for up to one month.
For preventing the loss of the effectiveness of nitroglycerin in relieving pain in people with chest pain due to coronary artery disease (angina pectoris): 700 mg four times daily.
For organic erectile dysfunction (ED): 5 grams per day. Taking lower doses might not be effective.
For preventing inflammation of the digestive tract in premature infants: 261 mg/kg added to oral feedings daily for the first 28 days of life.

Unrelated but more on Arginine..


www.healingwell.com/community/default.aspx?f=35&m=1863093

There are 3 L-Arginine Suppliments ( best if taken along with L-Ornithine and L-Citrulline for maximum synthesis)

1) L-Arginine is the most common, cheapest and least absorbing
2) Arginine Alpha-Ketoglutarate much more absorbable
3) L-Arginine Ethyl Ester, fastest possible absorption, hardest to locate unless online

Also ARG creates NO, here is all the good from NO..

healthiswealth.net/IgnarroArticle.pdf

Best link yet on the multitude of benefts from L-Arginine

www.drugs.com/npp/l-arginine.html

Post Edited (aguywithuc) : 8/24/2011 10:17:16 AM (GMT-6)

Posted 8/25/2011 12:14 PM (GMT 0)
aguywithuc,

Thanks for posting. This is very interesting.

So, do you attribute your UC symptoms decreasing due to use of Arginine Ethyl Ester?

How much do you take of it?

I am NOT a body builder, and have no interest in body building, therefore I am not too familiar with these types of products, but would be interested in trying this if  it could help with UC. I am doing whey protein shakes now (you can see from my sig), for nutritional purposes.

Is this the one I should order then? http://www.nutrabio.com/Products/arginine_ethyl_ester.htm

That's the place I buy my D-Ribose and L-Glutamine from.

Your input is greatly appreciated. Thanks.

 

Posted 8/25/2011 1:37 PM (GMT 0)

InSoFla said...
aguywithuc,

Thanks for posting. This is very interesting.

So, do you attribute your UC symptoms decreasing due to use of Arginine Ethyl Ester?

How much do you take of it?

I am NOT a body builder, and have no interest in body building, therefore I am not too familiar with these types of products, but would be interested in trying this if it could help with UC. I am doing whey protein shakes now (you can see from my sig), for nutritional purposes.

Is this the one I should order then? http://www.nutrabio.com/Products/arginine_ethyl_ester.htm

That's the place I buy my D-Ribose and L-Glutamine from.

Your input is greatly appreciated. Thanks.

Initial change was positive and no change since I started. This blue bottle from SNI is the only ethyl ester of L-Arginine I have tried and bought another one yesterday.

www.google.com/products/catalog?q=arginine+ethyl+ester+sni&um=1&ie=UTF-8&tbm=shop&cid=16892261231617240059&sa=X&ei=vU5WTs-lDKqqsQL3g7iQDA&ved=0CEgQ8wIwAQ

1 week - 10 days now. Doing great but watching for any reason to be concerned. Overall feel very healthy, workouts seem to have a soreness phase and a healing phase now, was not really feeling either before. So I feel back to normal and 20 years younger.

This right here tells me it has the chance to positively effect us :

Link said...
L-arginine significantly reduced vascular occlusion because of less inflammation, endothelial disruption, and thrombosis. L-arginine also decreased tubulitis, interstitial injury, and macrophage infiltration. These protective effects suggest that L-arginine might be useful as additive therapy to conventional immune suppression.

jasn.asnjournals.org/content/12/2/361.abstract

The list of good things L-Arginine does goes on forever.
Posted 8/25/2011 3:42 PM (GMT 0)
 

aguywithuc,

That's great - so it's really helping you!

I see you're taking the capsules, I can't swallow capsules they always get stuck and then I choke.

BTW, will this increase hair production too or decrease hair loss?

And does it do anything for libido loss too?

If so, that would be the trifecta!!LOL

Posted 8/25/2011 4:42 PM (GMT 0)

InSoFla said...
aguywithuc,

That's great - so it's really helping you!

I see you're taking the capsules, I can't swallow capsules they always get stuck and then I choke.

BTW, will this increase hair production too or decrease hair loss?

And does it do anything for libido loss too?

If so, that would be the trifecta!!LOL

Right now I feel like I have been suffering from a chronic inflammatory disease and now I am healing. Hair loss can be attributed to inflammation so hoping it helps and I am trying topical arginine to grow the thickest head of hair I can.

As far as Libido, well now my libido is waking me up at night, this is crazy, saw lots of comments about it and I have not felt this good since I was a young man in his 20's maybe 30's.

Vitamin Shoppe as those blue bottles in stores. I am not changing anything this is working for now.
Posted 8/25/2011 6:19 PM (GMT 0)
aguywithuc,

Sounds like it's really benefiting you in many ways. :-)

Posted 8/25/2011 9:25 PM (GMT 0)
The guys raving about the ED improvements are right. I don't have ED but my interest was way down I assumed from all the stimulants and long work hours. Turns out that is not the reason. I feel like my body has been unable to heal completely since UC. I mean any part of me, work out too much or use something too much and it would just get chronically inflamed too. Now I feel like I am healing.

However my body could adjust and level back out rendering it useless. It is terrific at doing that to almost anything put into it.

If I can make it one month with no flare and no fading effects I will stock up on this stuff because I expect to use it for the rest of my life.

Also I noticed that I stopped binging on bad food, I no longer crave sweets, I want real food with nutrition. That will also help with inflammation. Its a new thing for me to pass up treats. I think L-arg effects blood sugar control.

Post Edited (aguywithuc) : 8/25/2011 4:30:27 PM (GMT-6)

Posted 8/26/2011 8:19 PM (GMT 0)
aguywithuc what is the dose you are taking everyday?
Posted 8/26/2011 9:59 PM (GMT 0)

DanthaMan said...
aguywithuc what is the dose you are taking everyday?

I have a tendency to overdo everything. This is working so sticking with the recommended dose of 3 pills somewhere in the AM and 3 in the PM. I think its really 3 upon waking and 3 right before workout but I just spread them out. I think you can take a lot before any side effects. Hard to see dosing for Arginine-Ethyl-Ester, regular arginine is hardly absorbed and caused me problems.

So the SNI AEE bottle says 2200 mg for 3 capsules ( thank god I have seen the write-ups on taste and I remember it used to taste like dog-vomit we called it )
6 capsules daily, 3 30 mins before workout 3 immediately after workout.

So 2.2 grams morning and 2.2 grams afternoon puts me at 4.5 grams per day.
Posted 8/27/2011 7:17 PM (GMT 0)
I went to GNC and talked with the guy there for about 15 minutes about Arginine. I told him that I was looking for Arginine Ethyl Ester and he said thats an older formula and there is newer better formula out now. I told him that I had UC and he said he has two friends that have it as well and they take Yok3d. Its Arginine Nitrate and he said thats his best arginine supplement he has and absorbs better than AEE. I went ahead and bought it and going to give it a go.
Posted 8/27/2011 7:45 PM (GMT 0)

DanthaMan said...
I went to GNC and talked with the guy there for about 15 minutes about Arginine. I told him that I was looking for Arginine Ethyl Ester and he said thats an older formula and there is newer better formula out now. I told him that I had UC and he said he has two friends that have it as well and they take Yok3d. Its Arginine Nitrate and he said thats his best arginine supplement he has and absorbs better than AEE. I went ahead and bought it and going to give it a go.

Yeah I get mine at Vitamin Shoppe with two 'p's. Better probably means 'he sells it' but I would love to hear how it works for you. I like this 'Vitis vinifera, also known as grape seed extract, is rich in antioxidants and produces/fortifies elastin and collagen which help make up the connective tissue within the muscle'. I could use more collagen.

www.jack-3d.com/yok3d

Jack3d is a decent product and they make it too. I try not to take it because all those vaso-restrictors work opposite to vado-dilators and would cancel each other out. I have thought about jack3d to jump start my day, lift and switchover to dilators for the rest of the day. I have been 25% stronger on the dilators so jack3d may not be good for anything but mental alertness.

Well if it backfires its because I am not reading anything about how it is able to 'bypass' digestion. That is the only reason I use ethyl-ester.

If you find something regarding digestion please post it.

http://www.nitricoxidesupplementsite.com/arginine-nitrate

Labrada's AEE product says it bypasses digestion.

"A2-PumpTM bypasses the digestive system, it can be taken on an empty stomach or with a meal. For best results, use with C2-StrengthTM Creatine Ethyl Ester HCl."

White Blood AEE

"With esterfication, the arginine and ornithine can pass the digestive system intact and deliver incredible pumps and greater vasodilation than arginine AKG (alpha-ketoglutarate), which is contained in the most popular nitric oxide products, or any other nitric oxide enhancer could ever have achieved in the past."

http://www.supplementsource.ca/Controlled_Labs_White_Blood_p/controlled%20labs%20white%20floodcap.htm[url]

I can find this on AEE from SNI

WHY IS ARGININE ETHYL ESTER BETTER THAN ARGININE?

Arginine Ethyl Ester is 40 Times more effective than Arginine due in part to the Ester molecule. This allows your body to absorb Arginine Ethyl Ester instantly while benefiting from the optimal amount of Arginine.

Post Edited (aguywithuc) : 8/27/2011 2:07:40 PM (GMT-6)

Posted 8/27/2011 8:06 PM (GMT 0)
Here is some good info on AEE

docsprefer.com/panarginine-ee.aspx

Arginine ethyl ester can pass through the intestine largely intact so it can have a greater absorption rate which would increase the beneficial effects of the arginine while reducing the need for large doses.

Arginine Ethyl Ester for Men
Arginine has typically been considered a body builders supplement because it can provide the body with the necessary nutrients to help increase muscle mass when used in conjunction with weight lifting.* But while this is certainly a benefit, it is not the most important reason men could be supplementing their diet with arginine ethyl ester.

Precursor for the synthesis of Nitric Oxide (NO)*
Increasing body-wide circulation has many benefits.
Such as getting more blood to the heart, helping combat cold hands & feet and most importantly, increasing blood flow to the sex organs...see the link

Improves immune function*

Reduces risk of heart disease*

Helps decrease blood pressure*


Arginine Ethyl Ester for Women
Women can certainly benefit from the use of an Arginine supplement. With heart disease being the Number 1 killer among women, arginine added to the mix of daily nutritional supplements while combined with a sensible exercise program can greatly support healthy heart function. But this is only one reason why women could choose to use arginine ethyl ester. Here are some other reasons:

Increases circulation throughout the body, including the sex organs
Increasing circulation throughout the body, especially to the extremities (hands and feet), can help bring blood into those areas to bring warmth & to decrease the coldness.*
Increased circulation to the vagi....ok maybe you should just read the link..
Posted 1/31/2012 3:32 AM (GMT 0)
Getting back into weight lifting today and I purchase the blue bottle SNI brand that you did aguywithuc. Will post in a week with results, hopefully good news :)
Posted 2/1/2012 2:34 AM (GMT 0)
Hey I was just looking at a bottle at Vitamin Shoppe, there is one other brand out there but this one works perfectly. I never have a second thought about taking 3 pills 1,2,3 times a day. Great extra reps on the pumps.

Arginine ketyl glutarate -akg now that as well as straight arginine are a huge no-no for UC.

When I started taking it I had a lot of hypertension too probably from too much caffeine and it would always relax the cardiovascular system but its not much of an issue any more seems like a long term benefit. So I probably forget to take it every other day now but its also good as a replacement for an energy drink for mental boost as it gets more oxygen to the highly vascularized brain.

Good luck hope it improves your workouts.

They cannot tell if it is good or bad for UC, but clearly its not at all bad for my UC. 18 mos remission now.
Posted 2/1/2012 3:20 AM (GMT 0)
The latest, greatest for of arginine is agmatine. Has anyone tried that yet? Agmatine is the byproduct of arginine from which all the benefits come, or so they say.
Posted 2/1/2012 6:34 AM (GMT 0)
Not until now - Thanks :)

My concerns are :

1- Conflicting info, UC'rs have high arginine already
2- Aginine seems to help some and certainly myself
3- AEE absorbs directly no GI hassle, do not know about agmatine in the GI

Seems it has the opposite effect on NO than does arginine.

Agmatine

Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones.
(NOSs) are a family of enzymes that catalyze the production of nitric oxide (NO) from L-arginine.

Arginine

Precursor for the synthesis of nitric oxide (NO) { I read that as gets 'synthased' and opposite to Agmatine }

Arginine is a conditionally nonessential amino acid, meaning most of the time it can be manufactured by the human body, and does not need to be obtained directly through the diet. The biosynthetic pathway however does not produce sufficient arginine, and some must still be consumed through diet. Individuals who have poor nutrition or certain physical conditions may be advised to increase their intake of foods containing arginine. Arginine is found in a wide variety of foods, including.

Please correct my analysis if it is incorrect.
Posted 2/1/2012 6:04 PM (GMT 0)
I see what you saw but I don't understand it, I guess. See below, I think you are talking about the first two benefits listed, I just don't know why that is bad or contradicts arginine. I'm not arguing your point, btw, this is just beyond my knowledge.

Agmatine Summary of Benefits:

* Increased Nitric Oxide Syntheses
* Inhibit NO Synthase (the enzyme responsible for NO breakdown)
* Stimulation of L.H. (Luteinizing Hormone) & G.H. (Growth Hormone) Levels
* Promote a Healthy & Positive Mood (Anti-Anxiety & Antidepressant Properties)
* Promote Nutrient Delivery to Muscle Cells
* Supports Overall Anabolic Environment
* Enhanced Insulin Response
* Neuroprotective Support
* Cardiovascular Health
* Antioxidant
Posted 2/2/2012 10:33 PM (GMT 0)
well, it seems to really make me go alot more. I think it could be the magnesium sterate in it but at this point I am not sure. Could it be a detox of sorts?
Posted 2/3/2012 6:51 AM (GMT 0)

Gonk said...
I see what you saw but I don't understand it, I guess. See below, I think you are talking about the first two benefits listed, I just don't know why that is bad or contradicts arginine. I'm not arguing your point, btw, this is just beyond my knowledge.

Agmatine Summary of Benefits:

* Increased Nitric Oxide Syntheses
* Inhibit NO Synthase (the enzyme responsible for NO breakdown)
* Stimulation of L.H. (Luteinizing Hormone) & G.H. (Growth Hormone) Levels
* Promote a Healthy & Positive Mood (Anti-Anxiety & Antidepressant Properties)
* Promote Nutrient Delivery to Muscle Cells
* Supports Overall Anabolic Environment
* Enhanced Insulin Response
* Neuroprotective Support
* Cardiovascular Health
* Antioxidant

I like your info better - I will have to give it a try

Thanks!
Posted 2/3/2012 6:55 AM (GMT 0)

DanthaMan said...
well, it seems to really make me go alot more. I think it could be the magnesium sterate in it but at this point I am not sure. Could it be a detox of sorts?

Bummer. I never noticed the 'other' ingredients. I have never associated its use with any change in GI patterns. It seemed kind of inert regarding UC.
Posted 2/9/2012 6:42 PM (GMT 0)
Yeah I had to stop taking it since it was increasing frequency and I saw blood.

What about this supplement

http://www.iherb.com/Nutrex-Research-Labs-NIOX-Maximum-Impact-Nitric-Oxide-Stimulator-180-Fast-Acting-Liqui-Caps/25691?at=0

??
Posted 2/9/2012 8:26 PM (GMT 0)

DanthaMan said...
Yeah I had to stop taking it since it was increasing frequency and I saw blood.

What about this supplement

http://www.iherb.com/Nutrex-Research-Labs-NIOX-Maximum-Impact-Nitric-Oxide-Stimulator-180-Fast-Acting-Liqui-Caps/25691?at=0

??

I will stop recommending it.

This looks good "L-Arginine Ethyl Ester Dichloride". Let us know if its better on your GI system.
Posted 2/9/2012 9:34 PM (GMT 0)
I've been taking Agmatine. It's too early to tell if it's helping but it's definitely not having any adverse effects on me. Dantha, be careful with these bodybuilding supps, most of them have tons of unnecessary crap in them that can do you harm. There are at least a couple of companies that make all natural BB supps that are excellent - I get supps from Muscle Feast and STS-Sports. Good stuff, everything declared, no fluff.
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