LDN

I'm thrilled for you. That's such great news. What a surprise, about your GI prescribing LDN.

Please tell me again: he didn't have you pitch it to him? He agreed right away? WOW!

Did you get a chance to speak with Skip? He's so knowledgeable and so nice.

I'd love my GI to be open to prescribing it.

Do you know how to take it? If not, let me know and I will explain it in detail.

As far as the LDN forums, I will gather them and post the links here for you, ok?

[email protected]

http://ldn.proboards.com/index.cgi?board=forum

Here are the 2 forums on LDN, as promised. You'll have to sign up to become a member of each forum group.

Hope this helps.

I'm looking forward to hearing great results from your LDN use. Are you also doing gluten, dairy, and wheat free? If so, you'll see results pretty quickly.

Sorry for the delay in getting back to you. I'm more than happy to help in any way I can .

I'm so glad you pushed back, when your GI suggested surgery. Good for you!

And I'm thrilled he agreed to prescribe the LDN.

The majority of the folks who did very well, very quickly on LDN (albeit oral or transdermal) did so because they were mostly on SCD diet or certainly dairy, wheat, and gluten free. IMO all those "irritants" inflame our guts/colons which never allow the inflammation to go down. LDN is an immune regulator, and it will "gear up" your system in the way it needs so that healing can occur. However, if you keep adding daily "irritants" to the equation, it never allows LDN to do its work.

That's the reason I asked you about diet. Once you've been taking LDN for 6 months +, alot of the healing has already taken place, and some folks can actually add back some of those "irritants" although perhaps on more of an occasional basis rather than daily basis. Unfortunately, we've all been programmed to believe, eat, get addicted to foods which are just not very healthy  for us (you know the list as you've read the Mercola articles). As I mentioned before, I do cheat once in a while, but when I do, I take care to double my slippery elm/VSL#3 cocktail to ensure the least damage. The way I look at it, all these irritant foods are inflammatory, and since we know inflammation is the cause of disease (IBD, UC, many others including cancer), why chance it? But I know it's hard - due to cultural indoctrination :(

So, when I started on transdermal LDN, on day FOUR  I started to see major results, then within a week bleeding stopped entirely.

I was pretty much on SCD, with occasional cheating when I started LDN, and believe that's why I did so well, so quickly.

I've heard the same scenario from others, and for those who've tried LDN and stayed on their non-SCD diet, it takes a little longer (a few weeks to see the changes).

BTW, when I tried the oral LDN with avicel filler (which I had a reaction to), I got the "flu" for about 24 hours, which I attribute to LDN gearing up my immune system. I had to end up switching to transdermal because of my allergic reaction to the avicel filler and malabsorption issues as well - and the only side effects I got then, was very vivid dreams, no sleeplessness.

I rather enjoyed the vivid dreams! On that note, I would caution you to make sure whatever you experience (whether in a book, on tv, or environment) within a few hours of sleep should be pleasant and calming to ensure your vivid dreams will be pleasant. I've heard of some who love horror movies and watch them before going to sleep... well guess what kind of vivid dreams they experienced? Nightmares! Not a whole lot of fun :(

Now, as far as putting on the LDN: you'll be applying the dosed cream anywhere between 10pm and 2 am (via a syringe type implement) to your skin and rubbing it in, until it's mostly absorbed. Then you'll let it air dry - which will take about 15 minutes. You can wash it off in the morning, and it won't have any effect on the LDN absorption. I would highly recommend your switching the sites of application, alternating left and right sides of: the back of the forearm -area above the wrist where the veins are prominent, top of the hands, top of the feet. These are all areas where the skin is thin, and veins are prominent.

I'd like to give you my personal email so that if you have any questions, I can answer them directly for you, and also so we can keep in touch:  [email protected]. Feel free to be in touch. I would love to hear from you.

Let me know if there's something I've omitted addressing for you.

I'll be cheering for you.

Sorry for the long post.

Further info from the research doctors on LDN, and splitting the dosage, etc....

BTW, I am taking a full dose @ 4.5mg transdermal LDN every night around 10pm, and have wonderfully vivid dreams.

This was posted on the LDNandIBD yahoo forum by Jayne. I thought you might find it interesting:

"Dr Gilhooly is experimenting with his patients and is focussing on LDN’s effect with the TLR4 receptors (anti inflammatory response). Whilst LDN has anti inflammatory properties, they are not in abundance so Dr Gilhooly believes that dosing every 12 hours gives people enough time to get LDN out of their system for the benefits of OGF, and then block the opioid receptors again to gain an anti inflammatory response. This came out of Dr Jarred Younger’s study on fibro (about the two molecules LDN has – one for anti inflammatory, the other for the endorphin effect).

Dr Zagon is not in favour of split dosing as his studies back in the 80’s show you are risking the amount of ‘good’ you get from LDN by only having a 6 hour window (remember, LDN is supposedly out of your system in 4-6 hours, so you’d have 6 hours for OGF to do its work before blocking the opiate receptors again. In fact, he opposes it.

I contacted Dr Younger on this issue and he agrees it’s not worth shortening the amount of OGF you have in your system for the TLR4 effect. However, he also believes it’s OK to try under the supervision of a Dr.

Having said the above, a number of people are split dosing and double dosing and seem to be doing fine on it. Bear in mind, the effect Dr Gilhooly is trying to achieve is experimental and Dr Zagon’s concerned about the possible harm there may be by people dosing like this further down the road ie if they have an underlying illness. With some patients Dr Gilhooly believes you should also take as much LDN as you can tolerate ie until you hit the wall (you feel so fatigued you can’t do anything else). With some, he has them start low and increase 0.5mg every two weeks until they get that effect, then he will suggest you divide the dose in to two."

Let me know when you start the LDN cream.