Hello All,
I was searching through the forums for anyone with side effects involving the kidneys while using Mesalamine products. I couldn't find any so I'll just ask. 
As for a little history, Im 23, 130lbs and in good health. In 2010 I was having alot of nausea and vomiting. Strangly, it was only in the early morning hours while I was sleeping, and 2 -3 times a week. I seen a gastroenterologist who tested my blood for gluten sensitivity. It came back boderline so I was scheduled for an upper endoscopy. My biopsy was negative, allthough, I figured the gluten free diet wouldn't hurt, and if it stopped the vomiting then it'd be worth it. And surely enough, it helped. 6 months later though, i had awful stomach pain. worse than your worse stomach ache. I would eat and about an hour later I'd get stomach pains and I would almost pass out. I'd be really hot, partially loose either my vision or hearing or both, and I remember my ears being extremely hot. Then I would have diarhea for days until I took Imodium. I went to the ER after i couldnt stand it anymore. I was referred to another GI dr who scheduled me for a colonoscopy. My gluten sensitivity blood work was repeated, and the number was extremely high. Normal was 11, and mine was in the 50's. My colon looked perfect, (which I'm proud that I did my own prep with Miralax and gatorade since the prep they prescribed made me have flu like symptoms). But my biopsy came back with Microscopic colitis in both the ascending and descending colon. (thats actually the only places they took the biopsy from). So the doctor said that my colitis was causing my reaction to gluten. I also had slightly low b12 levels, which i now feel like the extreme pain associated with passing out was releived with b12. Anyways to the point now! I was given Apriso 6 caps every morning. My bowel movements were still loose and i seen alot of the medication in my stools. I noticed that 2 mornings when i went to pee, my urine was really dark. almost like tea. Never in my life have I seen this. I also had a prescription for Asacol so i switched myself to that. After about a week or two of the medication, I noticed one day that i couldn't pee. I had drank about 28 - 32oz of liquid, and usually I'd have to pee within a few hours. I went a little bit but i knew it wasnt normal for what i had drank. For the rest of the day, I didn't have the urge to go, but i would try. I decided to stop taking my Asacol and my birth control. So the next morning i had gotten some cranberry grape juice and drank about 2oz of that and a small amount of water and layed down. i had pressure on my abdomen. i also felt ill. Just that general sick feeling and too tired to get out of bed. when i woke i did have to pee but it still wasn't a normal amount. It was also clear. Later that evening, probably around 6pm, i was frustrated and drank another bottle of water with more cranberry juice. Finally at 4am the next morning i had to pee, and alot! I noticed it was a dark yellow and it sunk to the bottom instead of mixing with the water like normal. I called my doctor to inform him of my problem and he told me to switch to 2 tabs of Asacol twice a day instead of the 3 tabs twice a day that i was taking. (and honestly, i had been forgetting some doses at that). I'm familiar with uti's and also interstitial cystitis, which both cause burning, urgency, etc. With this, i had the completely opposite. I went to my general dr and she tested for infection but i was fine. she sent it for a culture and that came back fine as well. If this is something normal, then i'm okay with this. But i'd like to look out for my kidneys in the long run. the last thing i want to do is to need a kidney transplant in a few years. I went to the GI today, i brought up the urinating problems and he just didn't seem to care. everytime i brought it up, he was concerned about how it was helping my diarrhea. A part of me wants to listen to him because he's the doctor, not me. but another part of me says i know my body better than anyone else and i feel like my body is saying something. Also i have extreme gas pains when i take asacol. I have to lay in certain positions just to get rid of it. He thinks its from the colitis but ive never been a gassy person. and when i stop taking mesalamine, i stop having gas pressure and pain. I also feel that I have proctitis as well. i mean if it's in my ascending and descending colon, it's probably further down "there" as well, right? At times, i feel constipated when i shouldn't be, I feel the consistent urge to go even when i just went. he says its the colitis and tried to increase my asacol back up to 3 tabs, then i had to remind him about my peeing problems! :(. He said the other option is prednisone which he doesnt want to do. and neither do i!! I've worked in a pharmacy for 4yrs and now at an insurance company so i'm always reading clinical notes and i know there are other meds out there like budesonide and suppository and enema forms of mesalamine. I'm just so confused. :( please help!