can't stop the accidents....advice/ideas

Lialda tends to make my stool looser when I am on the max dose. Have you used the enemas nightly for any length of time or just sporadically?

Are you laying on your left side when you do them? I really only have the uncomfortable feeling for a minute or two. Staying on the left side is key though if I move around I feel more crampy. Do you have the 4g Rowasa? Try only doing half of it for a few days or even half and an hour later another half. Maybe it won't be so bad then. They are really key in feeling well though. I hate them too but I hate having the urgency and possible accidents waaaay more.

true- I've been wearing some sort of panty liner or pad daily for like the past 3 years... accidents SUCK, no doubt about that, but if you're prepared, it takes a lot of the hassle out. I carry around a ziplock baggie with extra undies, baby wipes, another ziplock bag, more panty liners... so if I'm at work, I can clean up, change, & jsut go on about my day. I always have a bag of stuff in my car & one of my purse. Sounds dorky, but... it's way better than being caught short, with dirty underpants! On another note- Imuran is not a drug to be scared of, I've been on it for years now & I swear that one med has done more for my UC than any biologic. I hate rectal meds too, never use them... Maybe 2-3 times a year????

running to the toilet and sometimes making it .....or..... rectal meds -

for me it's a no braiiner - i usually have no problem falling asleep after about 15 minutes of being very uncomfortable - wake up in the morning ready to take on the world with no worries -

just doo it or poo it

Yes I think trying LDN is a no-brainer- cheap, non-toxic, well worth trying. You'll need to search for integrative medicine docs or doctors of osteopathy to rx it for you, so the main cost if you dont already have such a doc would be paying for an initial consult. Its extremely rare for a GI to not dismiss interest in something like LDN.

I personally didn't want to take 6mp or Imuran either but the idea of an accident scares me a lot more than the repercussions of these medications. They have been around for a long time and have good safety statistics.

I think you may see more benefit from Rowasa if you're inflamed. Perhaps Rowasa in the PM and Canasa in the AM for a while and see how you do? Even a steroid enema before bed may be helpful and it's better than immune supression if it's not warranted. You can always taper off the steroid enemas after a few weeks and hopefully maintain on 5ASA rectals.