I've been taking it for 1 1/2 years. I don't think it works as well as Remicade did--I see a lot more flutation of my symptoms than I did on Remicade--but it is certainly easier. I recently had the beginnings of a flair and am now taking it once a week, rather than once every two weeks. So far things are going pretty well. I take the shot in my stomach b/c, as someone mentioned above, it hurts less than the thigh. I also take benadryl before the injection and have had very little allergic response to it. On occasion, the injection site is a bit red and itchy, but overall I've had very few side effects that I would attribute to Humira.
Wishing you the best of luck!
B